CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality

The authors show that the CD200 receptor (CD200R) promotes effective clearance of pulmonary Francisella tularensis infection in knock out mice. This result is unexpected as CD200R is known to dampen pulmonary immune responses, and these data suggest that the beneficial effect against F. tularensis i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	J. Casulli, M. E. Fife, S. A. Houston, S. Rossi, J. Dow, E. D. Williamson, G. C Clark, T. Hussell, R. V. D’Elia, M. A Travis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/863531790019429fb219fb31b164b0b1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:863531790019429fb219fb31b164b0b1
record_format	dspace
spelling	oai:doaj.org-article:863531790019429fb219fb31b164b0b12021-12-02T14:40:17ZCD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality10.1038/s41467-019-10156-62041-1723https://doaj.org/article/863531790019429fb219fb31b164b0b12019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10156-6https://doaj.org/toc/2041-1723The authors show that the CD200 receptor (CD200R) promotes effective clearance of pulmonary Francisella tularensis infection in knock out mice. This result is unexpected as CD200R is known to dampen pulmonary immune responses, and these data suggest that the beneficial effect against F. tularensis is due to depletion of a neutrophil niche for the bacterium.J. CasulliM. E. FifeS. A. HoustonS. RossiJ. DowE. D. WilliamsonG. C ClarkT. HussellR. V. D’EliaM. A TravisNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. Casulli M. E. Fife S. A. Houston S. Rossi J. Dow E. D. Williamson G. C Clark T. Hussell R. V. D’Elia M. A Travis CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
description	The authors show that the CD200 receptor (CD200R) promotes effective clearance of pulmonary Francisella tularensis infection in knock out mice. This result is unexpected as CD200R is known to dampen pulmonary immune responses, and these data suggest that the beneficial effect against F. tularensis is due to depletion of a neutrophil niche for the bacterium.
format	article
author	J. Casulli M. E. Fife S. A. Houston S. Rossi J. Dow E. D. Williamson G. C Clark T. Hussell R. V. D’Elia M. A Travis
author_facet	J. Casulli M. E. Fife S. A. Houston S. Rossi J. Dow E. D. Williamson G. C Clark T. Hussell R. V. D’Elia M. A Travis
author_sort	J. Casulli
title	CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
title_short	CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
title_full	CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
title_fullStr	CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
title_full_unstemmed	CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
title_sort	cd200r deletion promotes a neutrophil niche for francisella tularensis and increases infectious burden and mortality
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/863531790019429fb219fb31b164b0b1
work_keys_str_mv	AT jcasulli cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT mefife cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT sahouston cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT srossi cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT jdow cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT edwilliamson cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT gcclark cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT thussell cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT rvdelia cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality AT matravis cd200rdeletionpromotesaneutrophilnicheforfrancisellatularensisandincreasesinfectiousburdenandmortality
_version_	1718390368067649536

CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality

Ejemplares similares