Connecting different heart diseases through intercellular communication

Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell–cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectl...

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Autor principal: Tania Martins-Marques
Formato: article
Lenguaje:EN
Publicado: The Company of Biologists 2021
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Acceso en línea:https://doaj.org/article/8636120d76574135a7736d87f6760fc3
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spelling oai:doaj.org-article:8636120d76574135a7736d87f6760fc32021-11-28T16:01:15ZConnecting different heart diseases through intercellular communication2046-639010.1242/bio.058777https://doaj.org/article/8636120d76574135a7736d87f6760fc32021-09-01T00:00:00Zhttp://bio.biologists.org/content/10/9/bio058777https://doaj.org/toc/2046-6390Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell–cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell–extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author.Tania Martins-MarquesThe Company of Biologistsarticlegap junctionsextracellular vesiclestunneling nanotubescell-based therapiesmyocardial infarctioncardiac hypertrophyScienceQBiology (General)QH301-705.5ENBiology Open, Vol 10, Iss 9 (2021)
institution DOAJ
collection DOAJ
language EN
topic gap junctions
extracellular vesicles
tunneling nanotubes
cell-based therapies
myocardial infarction
cardiac hypertrophy
Science
Q
Biology (General)
QH301-705.5
spellingShingle gap junctions
extracellular vesicles
tunneling nanotubes
cell-based therapies
myocardial infarction
cardiac hypertrophy
Science
Q
Biology (General)
QH301-705.5
Tania Martins-Marques
Connecting different heart diseases through intercellular communication
description Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell–cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell–extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author.
format article
author Tania Martins-Marques
author_facet Tania Martins-Marques
author_sort Tania Martins-Marques
title Connecting different heart diseases through intercellular communication
title_short Connecting different heart diseases through intercellular communication
title_full Connecting different heart diseases through intercellular communication
title_fullStr Connecting different heart diseases through intercellular communication
title_full_unstemmed Connecting different heart diseases through intercellular communication
title_sort connecting different heart diseases through intercellular communication
publisher The Company of Biologists
publishDate 2021
url https://doaj.org/article/8636120d76574135a7736d87f6760fc3
work_keys_str_mv AT taniamartinsmarques connectingdifferentheartdiseasesthroughintercellularcommunication
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