Connecting different heart diseases through intercellular communication

Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell–cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectl...

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Autor principal:	Tania Martins-Marques
Formato:	article
Lenguaje:	EN
Publicado:	The Company of Biologists 2021
Materias:	gap junctions extracellular vesicles tunneling nanotubes cell-based therapies myocardial infarction cardiac hypertrophy Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8636120d76574135a7736d87f6760fc3
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spelling	oai:doaj.org-article:8636120d76574135a7736d87f6760fc32021-11-28T16:01:15ZConnecting different heart diseases through intercellular communication2046-639010.1242/bio.058777https://doaj.org/article/8636120d76574135a7736d87f6760fc32021-09-01T00:00:00Zhttp://bio.biologists.org/content/10/9/bio058777https://doaj.org/toc/2046-6390Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell–cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell–extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author.Tania Martins-MarquesThe Company of Biologistsarticlegap junctionsextracellular vesiclestunneling nanotubescell-based therapiesmyocardial infarctioncardiac hypertrophyScienceQBiology (General)QH301-705.5ENBiology Open, Vol 10, Iss 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gap junctions extracellular vesicles tunneling nanotubes cell-based therapies myocardial infarction cardiac hypertrophy Science Q Biology (General) QH301-705.5
spellingShingle	gap junctions extracellular vesicles tunneling nanotubes cell-based therapies myocardial infarction cardiac hypertrophy Science Q Biology (General) QH301-705.5 Tania Martins-Marques Connecting different heart diseases through intercellular communication
description	Well-orchestrated intercellular communication networks are pivotal to maintaining cardiac homeostasis and to ensuring adaptative responses and repair after injury. Intracardiac communication is sustained by cell–cell crosstalk, directly via gap junctions (GJ) and tunneling nanotubes (TNT), indirectly through the exchange of soluble factors and extracellular vesicles (EV), and by cell–extracellular matrix (ECM) interactions. GJ-mediated communication between cardiomyocytes and with other cardiac cell types enables electrical impulse propagation, required to sustain synchronized heart beating. In addition, TNT-mediated organelle transfer has been associated with cardioprotection, whilst communication via EV plays diverse pathophysiological roles, being implicated in angiogenesis, inflammation and fibrosis. Connecting various cell populations, the ECM plays important functions not only in maintaining the heart structure, but also acting as a signal transducer for intercellular crosstalk. Although with distinct etiologies and clinical manifestations, intercellular communication derailment has been implicated in several cardiac disorders, including myocardial infarction and hypertrophy, highlighting the importance of a comprehensive and integrated view of complex cell communication networks. In this review, I intend to provide a critical perspective about the main mechanisms contributing to regulate cellular crosstalk in the heart, which may be considered in the development of future therapeutic strategies, using cell-based therapies as a paradigmatic example. This Review has an associated Future Leader to Watch interview with the author.
format	article
author	Tania Martins-Marques
author_facet	Tania Martins-Marques
author_sort	Tania Martins-Marques
title	Connecting different heart diseases through intercellular communication
title_short	Connecting different heart diseases through intercellular communication
title_full	Connecting different heart diseases through intercellular communication
title_fullStr	Connecting different heart diseases through intercellular communication
title_full_unstemmed	Connecting different heart diseases through intercellular communication
title_sort	connecting different heart diseases through intercellular communication
publisher	The Company of Biologists
publishDate	2021
url	https://doaj.org/article/8636120d76574135a7736d87f6760fc3
work_keys_str_mv	AT taniamartinsmarques connectingdifferentheartdiseasesthroughintercellularcommunication
_version_	1718407842615001088

Connecting different heart diseases through intercellular communication

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