APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

Abstract Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma F...

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Autores principales: Rosalind Fallaize, Andrew L. Carvalho-Wells, Audrey C. Tierney, Carmen Marin, Beata Kieć-Wilk, Aldona Dembińska-Kieć, Christian A. Drevon, Catherine DeFoort, José Lopez-Miranda, Ulf Risérus, Wim H. Saris, Ellen E. Blaak, Helen M. Roche, Julie A. Lovegrove
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Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8637a98a98904e97849beb62b8e207f6
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spelling oai:doaj.org-article:8637a98a98904e97849beb62b8e207f62021-12-02T12:30:19ZAPOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome10.1038/s41598-017-05802-22045-2322https://doaj.org/article/8637a98a98904e97849beb62b8e207f62017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05802-2https://doaj.org/toc/2045-2322Abstract Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.Rosalind FallaizeAndrew L. Carvalho-WellsAudrey C. TierneyCarmen MarinBeata Kieć-WilkAldona Dembińska-KiećChristian A. DrevonCatherine DeFoortJosé Lopez-MirandaUlf RisérusWim H. SarisEllen E. BlaakHelen M. RocheJulie A. LovegroveNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Rosalind Fallaize
Andrew L. Carvalho-Wells
Audrey C. Tierney
Carmen Marin
Beata Kieć-Wilk
Aldona Dembińska-Kieć
Christian A. Drevon
Catherine DeFoort
José Lopez-Miranda
Ulf Risérus
Wim H. Saris
Ellen E. Blaak
Helen M. Roche
Julie A. Lovegrove
APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
description Abstract Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.
format article
author Rosalind Fallaize
Andrew L. Carvalho-Wells
Audrey C. Tierney
Carmen Marin
Beata Kieć-Wilk
Aldona Dembińska-Kieć
Christian A. Drevon
Catherine DeFoort
José Lopez-Miranda
Ulf Risérus
Wim H. Saris
Ellen E. Blaak
Helen M. Roche
Julie A. Lovegrove
author_facet Rosalind Fallaize
Andrew L. Carvalho-Wells
Audrey C. Tierney
Carmen Marin
Beata Kieć-Wilk
Aldona Dembińska-Kieć
Christian A. Drevon
Catherine DeFoort
José Lopez-Miranda
Ulf Risérus
Wim H. Saris
Ellen E. Blaak
Helen M. Roche
Julie A. Lovegrove
author_sort Rosalind Fallaize
title APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
title_short APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
title_full APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
title_fullStr APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
title_full_unstemmed APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome
title_sort apoe genotype influences insulin resistance, apolipoprotein cii and ciii according to plasma fatty acid profile in the metabolic syndrome
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8637a98a98904e97849beb62b8e207f6
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