Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity

Feifei Ren,1 Rongjuan Guo2 1Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, People’s Republic of ChinaCorresp...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ren F, Guo R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	depression synaptic plasticity synaptic microenvironment glia influence factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8638d5d987e745c3925136aa11c736b2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8638d5d987e745c3925136aa11c736b2
record_format	dspace
spelling	oai:doaj.org-article:8638d5d987e745c3925136aa11c736b22021-12-02T13:51:18ZSynaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity1178-2021https://doaj.org/article/8638d5d987e745c3925136aa11c736b22021-01-01T00:00:00Zhttps://www.dovepress.com/synaptic-microenvironment-in-depressive-disorder-insights-from-synapti-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Feifei Ren,1 Rongjuan Guo2 1Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, People’s Republic of ChinaCorrespondence: Rongjuan GuoDepartment of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6, 1st Section, Fangxingyuan, Fangzhuang, Fengtai District, Beijing City, People’s Republic of ChinaTel/Fax +86 10-6768-9655Email 381160563@qq.comAbstract: Depression is a major disease that can affect both mental and physical health, limits psychosocial functioning and diminishes the quality of life. But its complex pathogenesis remains poorly understood. The dynamic changes of synaptic structure and function, known as synaptic plasticity, occur with the changes of different cellular microenvironment and are closely related to learning and memory function. Accumulating evidence implies that synaptic plasticity is integrally involved in the pathological changes of mood disorders, especially in depressive disorder. However, the complex dynamic process of synaptic plasticity is influenced by many factors. Here, we reviewed and discussed various factors affecting synaptic plasticity in depression, and proposed a specific framework named synaptic microenvironment, which may be critical for synaptic plasticity under pathological conditions. Based on this concept, we will show how we understand the balance between the synaptic microenvironment and the synaptic plasticity network in depression. Finally, we point out the clinical significance of the synaptic microenvironment in depression.Keywords: depression, synaptic plasticity, synaptic microenvironment, glia, influence factorsRen FGuo RDove Medical Pressarticledepressionsynaptic plasticitysynaptic microenvironmentgliainfluence factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 157-165 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression synaptic plasticity synaptic microenvironment glia influence factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression synaptic plasticity synaptic microenvironment glia influence factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ren F Guo R Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
description	Feifei Ren,1 Rongjuan Guo2 1Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing, 100029, People’s Republic of China; 2Department of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, People’s Republic of ChinaCorrespondence: Rongjuan GuoDepartment of Neurology, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6, 1st Section, Fangxingyuan, Fangzhuang, Fengtai District, Beijing City, People’s Republic of ChinaTel/Fax +86 10-6768-9655Email 381160563@qq.comAbstract: Depression is a major disease that can affect both mental and physical health, limits psychosocial functioning and diminishes the quality of life. But its complex pathogenesis remains poorly understood. The dynamic changes of synaptic structure and function, known as synaptic plasticity, occur with the changes of different cellular microenvironment and are closely related to learning and memory function. Accumulating evidence implies that synaptic plasticity is integrally involved in the pathological changes of mood disorders, especially in depressive disorder. However, the complex dynamic process of synaptic plasticity is influenced by many factors. Here, we reviewed and discussed various factors affecting synaptic plasticity in depression, and proposed a specific framework named synaptic microenvironment, which may be critical for synaptic plasticity under pathological conditions. Based on this concept, we will show how we understand the balance between the synaptic microenvironment and the synaptic plasticity network in depression. Finally, we point out the clinical significance of the synaptic microenvironment in depression.Keywords: depression, synaptic plasticity, synaptic microenvironment, glia, influence factors
format	article
author	Ren F Guo R
author_facet	Ren F Guo R
author_sort	Ren F
title	Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
title_short	Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
title_full	Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
title_fullStr	Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
title_full_unstemmed	Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity
title_sort	synaptic microenvironment in depressive disorder: insights from synaptic plasticity
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8638d5d987e745c3925136aa11c736b2
work_keys_str_mv	AT renf synapticmicroenvironmentindepressivedisorderinsightsfromsynapticplasticity AT guor synapticmicroenvironmentindepressivedisorderinsightsfromsynapticplasticity
_version_	1718392390438354944

Synaptic Microenvironment in Depressive Disorder: Insights from Synaptic Plasticity

Ejemplares similares