Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

Macropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	John C. Charpentier, Di Chen, Philip E. Lapinski, Jackson Turner, Irina Grigorova, Joel A. Swanson, Philip D. King
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/863ae641e6d64e65b74baab500a58bce
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:863ae641e6d64e65b74baab500a58bce
record_format	dspace
spelling	oai:doaj.org-article:863ae641e6d64e65b74baab500a58bce2021-12-02T14:42:30ZMacropinocytosis drives T cell growth by sustaining the activation of mTORC110.1038/s41467-019-13997-32041-1723https://doaj.org/article/863ae641e6d64e65b74baab500a58bce2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13997-3https://doaj.org/toc/2041-1723Macropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to an endolysosomal compartment to sustain mTORC1 activation.John C. CharpentierDi ChenPhilip E. LapinskiJackson TurnerIrina GrigorovaJoel A. SwansonPhilip D. KingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q John C. Charpentier Di Chen Philip E. Lapinski Jackson Turner Irina Grigorova Joel A. Swanson Philip D. King Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
description	Macropinocytosis has been implicated in the expansion of transformed cells when nutrient-depleted. Here the authors show that macropinocytosis also contributes to the expansion of primary T cells even under nutrient-replete conditions, potentially by providing access of extracellular amino acids to an endolysosomal compartment to sustain mTORC1 activation.
format	article
author	John C. Charpentier Di Chen Philip E. Lapinski Jackson Turner Irina Grigorova Joel A. Swanson Philip D. King
author_facet	John C. Charpentier Di Chen Philip E. Lapinski Jackson Turner Irina Grigorova Joel A. Swanson Philip D. King
author_sort	John C. Charpentier
title	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_short	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_full	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_fullStr	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_full_unstemmed	Macropinocytosis drives T cell growth by sustaining the activation of mTORC1
title_sort	macropinocytosis drives t cell growth by sustaining the activation of mtorc1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/863ae641e6d64e65b74baab500a58bce
work_keys_str_mv	AT johnccharpentier macropinocytosisdrivestcellgrowthbysustainingtheactivationofmtorc1 AT dichen macropinocytosisdrivestcellgrowthbysustainingtheactivationofmtorc1 AT philipelapinski macropinocytosisdrivestcellgrowthbysustainingtheactivationofmtorc1 AT jacksonturner macropinocytosisdrivestcellgrowthbysustainingtheactivationofmtorc1 AT irinagrigorova macropinocytosisdrivestcellgrowthbysustainingtheactivationofmtorc1 AT joelaswanson macropinocytosisdrivestcellgrowthbysustainingtheactivationofmtorc1 AT philipdking macropinocytosisdrivestcellgrowthbysustainingtheactivationofmtorc1
_version_	1718389698505736192

Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

Ejemplares similares