Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody.

Most forms of chronic pain are inadequately treated by present therapeutic options. Compelling evidence has accumulated, demonstrating that Nerve Growth Factor (NGF) is a key modulator of inflammatory and nociceptive responses, and is a promising target for the treatment of human pathologies linked...

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Main Authors: Sonia Covaceuszach, Sara Marinelli, Ivet Krastanova, Gabriele Ugolini, Flaminia Pavone, Doriano Lamba, Antonino Cattaneo
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2012
Subjects:
R
Q
Online Access:https://doaj.org/article/863bba9b7db841b1a0914d87b29bdf05
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