Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population

Masao Yoshida,1,* Akira Meguro,2,* Atsushi Yoshino,2 Naoko Nomura,2 Eiichi Okada,3 Nobuhisa Mizuki21Department of Public Health, Kyorin University School of Medicine, Mitaka, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama...

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Autores principales:	Yoshida M, Meguro A, Yoshino A, Nomura N, Okada E, Mizuki N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/863c2067f2f340718f36d5b96339625e
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spelling	oai:doaj.org-article:863c2067f2f340718f36d5b96339625e2021-12-02T03:38:23ZAssociation study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population1177-54671177-5483https://doaj.org/article/863c2067f2f340718f36d5b96339625e2013-10-01T00:00:00Zhttp://www.dovepress.com/association-study-of-igf1-polymorphisms-with-susceptibility-to-high-my-a14690https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Masao Yoshida,1,* Akira Meguro,2,* Atsushi Yoshino,2 Naoko Nomura,2 Eiichi Okada,3 Nobuhisa Mizuki21Department of Public Health, Kyorin University School of Medicine, Mitaka, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan; 3Okada Eye Clinic, Yokohama, Kanagawa, Japan*These authors contributed equally to this workPurpose: Polymorphisms in the insulin-like growth factor 1 (IGF1) gene were previously associated with high or extreme myopia in Caucasian and Chinese populations. In the present study, we investigated whether IGF1 polymorphisms are associated with high myopia in a Japanese population.Methods: A total of 446 Japanese patients with high myopia (≤–9.00 diopters) and 481 Japanese healthy controls (+1.50 diopters to –1.50 diopters) were recruited. We genotyped seven tagging single-nucleotide polymorphisms (SNPs) in IGF1 and assessed allelic and haplotypic diversity in cases and controls.Results: There were no statistically significant differences in the allele frequencies of IGF1 SNPs and genotypes between cases and controls (P>0.05). However, the A allele of rs5742629 and the G allele of rs12423791 were associated with a moderately increased risk of high myopia (odds ratio [OR] =1.20 and OR =1.21, respectively) with borderline statistical significance (P=0.0502, corrected P (Pc) =0.21 and P=0.064, Pc=0.29, respectively). The haplotype consisting of the A allele of rs5742629 and the G allele of rs12423791 was marginally associated with the risk of high myopia (P=0.041; OR =1.21); this association was not significant after correction (Pc=0.19).Conclusion: We found that the IGF1 SNPs are not significantly associated with high myopia in our Japanese population. Our results are in contrast to a previous study in which extreme myopia cases had significantly higher frequencies of the G allele of rs5742629 and the C allele of rs12423791 than controls. Therefore, the IGF1 SNPs may not be important factors for susceptibility to high myopia in all populations. Further genetic studies are needed to elucidate the possible contributions of the IGF1 region to the development of high myopia.Keywords: high myopia, IGF1, association study, polymorphismYoshida MMeguro AYoshino ANomura NOkada EMizuki NDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 2057-2062 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yoshida M Meguro A Yoshino A Nomura N Okada E Mizuki N Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population
description	Masao Yoshida,1,* Akira Meguro,2,* Atsushi Yoshino,2 Naoko Nomura,2 Eiichi Okada,3 Nobuhisa Mizuki21Department of Public Health, Kyorin University School of Medicine, Mitaka, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan; 3Okada Eye Clinic, Yokohama, Kanagawa, Japan*These authors contributed equally to this workPurpose: Polymorphisms in the insulin-like growth factor 1 (IGF1) gene were previously associated with high or extreme myopia in Caucasian and Chinese populations. In the present study, we investigated whether IGF1 polymorphisms are associated with high myopia in a Japanese population.Methods: A total of 446 Japanese patients with high myopia (≤–9.00 diopters) and 481 Japanese healthy controls (+1.50 diopters to –1.50 diopters) were recruited. We genotyped seven tagging single-nucleotide polymorphisms (SNPs) in IGF1 and assessed allelic and haplotypic diversity in cases and controls.Results: There were no statistically significant differences in the allele frequencies of IGF1 SNPs and genotypes between cases and controls (P>0.05). However, the A allele of rs5742629 and the G allele of rs12423791 were associated with a moderately increased risk of high myopia (odds ratio [OR] =1.20 and OR =1.21, respectively) with borderline statistical significance (P=0.0502, corrected P (Pc) =0.21 and P=0.064, Pc=0.29, respectively). The haplotype consisting of the A allele of rs5742629 and the G allele of rs12423791 was marginally associated with the risk of high myopia (P=0.041; OR =1.21); this association was not significant after correction (Pc=0.19).Conclusion: We found that the IGF1 SNPs are not significantly associated with high myopia in our Japanese population. Our results are in contrast to a previous study in which extreme myopia cases had significantly higher frequencies of the G allele of rs5742629 and the C allele of rs12423791 than controls. Therefore, the IGF1 SNPs may not be important factors for susceptibility to high myopia in all populations. Further genetic studies are needed to elucidate the possible contributions of the IGF1 region to the development of high myopia.Keywords: high myopia, IGF1, association study, polymorphism
format	article
author	Yoshida M Meguro A Yoshino A Nomura N Okada E Mizuki N
author_facet	Yoshida M Meguro A Yoshino A Nomura N Okada E Mizuki N
author_sort	Yoshida M
title	Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population
title_short	Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population
title_full	Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population
title_fullStr	Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population
title_full_unstemmed	Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population
title_sort	association study of igf1 polymorphisms with susceptibility to high myopia in a japanese population
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/863c2067f2f340718f36d5b96339625e
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Association study of IGF1 polymorphisms with susceptibility to high myopia in a Japanese population

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