Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

Psychiatric disorders are often accompanied by alterations in BMI and body composition due to changes in eating behaviour and physical activity. Here, Hübel et al. study the genetic overlap between these traits and find that genetic correlations between psychiatric disorders and body composition are...

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Autores principales: Christopher Hübel, Héléna A. Gaspar, Jonathan R. I. Coleman, Ken B. Hanscombe, Kirstin Purves, Inga Prokopenko, Mariaelisa Graff, Julius S. Ngwa, Tsegaselassie Workalemahu, ADHD Working Group of the Psychiatric Genomics Consortium, Meta-Analyses of Glucose and Insulin-related traits consortium (MAGIC), Autism Working Group of the Psychiatric Genomics Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Eating Disorders Working Group of the Psychiatric Genomics Consortium, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, OCD & Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, PTSD Working Group of the Psychiatric Genomics Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Sex Differences Cross Disorder Working Group of the Psychiatric Genomics Consortium, Substance Use Disorders Working Group of the Psychiatric Genomics Consortium, German Borderline Genomics Consortium, International Headache Genetics Consortium, Paul F. O’Reilly, Cynthia M. Bulik, Gerome Breen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/863cf5db36a34aa2af52cbcbf3287303
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Sumario:Psychiatric disorders are often accompanied by alterations in BMI and body composition due to changes in eating behaviour and physical activity. Here, Hübel et al. study the genetic overlap between these traits and find that genetic correlations between psychiatric disorders and body composition are sex-specific and evident only in adulthood.

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