CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

In atherosclerotic plaques, transformation of macrophages into foam cells is a key step in initiating the inflammatory response. Here Fan et al. show that casein kinase 2-interacting protein-1 (CKIP-1) limits foam cell formation and atherosclerosis by preventing expression of the scavenger receptor...

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Autores principales:	Jiao Fan, Lifeng Liu, Qingyan Liu, Yu Cui, Binwei Yao, Minghua Zhang, Yabing Gao, Yesheng Fu, Hongmiao Dai, Jingkun Pan, Ya Qiu, Cui Hua Liu, Fuchu He, Yu Wang, Lingqiang Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8646b6638a8d471db392995bb77aa1f4
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spelling	oai:doaj.org-article:8646b6638a8d471db392995bb77aa1f42021-12-02T17:01:52ZCKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ10.1038/s41467-018-07895-32041-1723https://doaj.org/article/8646b6638a8d471db392995bb77aa1f42019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07895-3https://doaj.org/toc/2041-1723In atherosclerotic plaques, transformation of macrophages into foam cells is a key step in initiating the inflammatory response. Here Fan et al. show that casein kinase 2-interacting protein-1 (CKIP-1) limits foam cell formation and atherosclerosis by preventing expression of the scavenger receptor LOX-1 through REGγ-mediated degradation of Oct-1.Jiao FanLifeng LiuQingyan LiuYu CuiBinwei YaoMinghua ZhangYabing GaoYesheng FuHongmiao DaiJingkun PanYa QiuCui Hua LiuFuchu HeYu WangLingqiang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jiao Fan Lifeng Liu Qingyan Liu Yu Cui Binwei Yao Minghua Zhang Yabing Gao Yesheng Fu Hongmiao Dai Jingkun Pan Ya Qiu Cui Hua Liu Fuchu He Yu Wang Lingqiang Zhang CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
description	In atherosclerotic plaques, transformation of macrophages into foam cells is a key step in initiating the inflammatory response. Here Fan et al. show that casein kinase 2-interacting protein-1 (CKIP-1) limits foam cell formation and atherosclerosis by preventing expression of the scavenger receptor LOX-1 through REGγ-mediated degradation of Oct-1.
format	article
author	Jiao Fan Lifeng Liu Qingyan Liu Yu Cui Binwei Yao Minghua Zhang Yabing Gao Yesheng Fu Hongmiao Dai Jingkun Pan Ya Qiu Cui Hua Liu Fuchu He Yu Wang Lingqiang Zhang
author_facet	Jiao Fan Lifeng Liu Qingyan Liu Yu Cui Binwei Yao Minghua Zhang Yabing Gao Yesheng Fu Hongmiao Dai Jingkun Pan Ya Qiu Cui Hua Liu Fuchu He Yu Wang Lingqiang Zhang
author_sort	Jiao Fan
title	CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
title_short	CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
title_full	CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
title_fullStr	CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
title_full_unstemmed	CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
title_sort	ckip-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of oct-1 by regγ
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8646b6638a8d471db392995bb77aa1f4
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CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

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