CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE

The aim of present work was to study some activation features of neutrophilic granulocytes from peripheral blood of the patients with G type of multiple myeloma (MM), as depending on clinical stage of the disorder. In this study, a number of parameters were evaluated, as follows: time dynamics of th...

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Autores principales:	O. V. Smirnova, V. T. Manchuk, Yu. N. Agilova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	multiple myeloma neutrophilic granulocytes chemiluminescence Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8647a7150ea3466fa65c4a5f63c543bb
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spelling	oai:doaj.org-article:8647a7150ea3466fa65c4a5f63c543bb2021-11-18T08:03:45ZCHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE1563-06252313-741X10.15789/1563-0625-2015-6-579-584https://doaj.org/article/8647a7150ea3466fa65c4a5f63c543bb2016-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/966https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of present work was to study some activation features of neutrophilic granulocytes from peripheral blood of the patients with G type of multiple myeloma (MM), as depending on clinical stage of the disorder. In this study, a number of parameters were evaluated, as follows: time dynamics of the up-to-maximum luminescence increase; maximal luminescence levels, areas under the curves (AUC) for the dynamic luminescence registration. Zymosan was used as chemiluminescence inducer, and luminol, as enhancer of the “respiratory burst”. The chemiluminescence enhancement was assessed as a ratio of AUC values corresponding to induced-to-spontaneous chemiluminescence being denoted as an ‘activation index’. The onset and progression of MM in humans was accompanied by disturbance of neutrophil functions. MM patients at stage II and III exhibited a significant increase of spontaneous ROS production relative to controls. The inducible ROS production by neutrophils was also increased in all groups, as compared with spontaneous production and and control parameters, thus arguing for a distinct role of neutrophils, as potentially cytotoxic effectors against tumor cells, along with their basic function of nonspecific antimicrobial protection.O. V. SmirnovaV. T. ManchukYu. N. AgilovaSPb RAACIarticlemultiple myelomaneutrophilic granulocyteschemiluminescenceImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 6, Pp 579-584 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	multiple myeloma neutrophilic granulocytes chemiluminescence Immunologic diseases. Allergy RC581-607
spellingShingle	multiple myeloma neutrophilic granulocytes chemiluminescence Immunologic diseases. Allergy RC581-607 O. V. Smirnova V. T. Manchuk Yu. N. Agilova CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE
description	The aim of present work was to study some activation features of neutrophilic granulocytes from peripheral blood of the patients with G type of multiple myeloma (MM), as depending on clinical stage of the disorder. In this study, a number of parameters were evaluated, as follows: time dynamics of the up-to-maximum luminescence increase; maximal luminescence levels, areas under the curves (AUC) for the dynamic luminescence registration. Zymosan was used as chemiluminescence inducer, and luminol, as enhancer of the “respiratory burst”. The chemiluminescence enhancement was assessed as a ratio of AUC values corresponding to induced-to-spontaneous chemiluminescence being denoted as an ‘activation index’. The onset and progression of MM in humans was accompanied by disturbance of neutrophil functions. MM patients at stage II and III exhibited a significant increase of spontaneous ROS production relative to controls. The inducible ROS production by neutrophils was also increased in all groups, as compared with spontaneous production and and control parameters, thus arguing for a distinct role of neutrophils, as potentially cytotoxic effectors against tumor cells, along with their basic function of nonspecific antimicrobial protection.
format	article
author	O. V. Smirnova V. T. Manchuk Yu. N. Agilova
author_facet	O. V. Smirnova V. T. Manchuk Yu. N. Agilova
author_sort	O. V. Smirnova
title	CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE
title_short	CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE
title_full	CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE
title_fullStr	CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE
title_full_unstemmed	CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE
title_sort	characteristics of neutrophil chemiluminescence in patients with type g multiple myeloma at different stages of the disease
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/8647a7150ea3466fa65c4a5f63c543bb
work_keys_str_mv	AT ovsmirnova characteristicsofneutrophilchemiluminescenceinpatientswithtypegmultiplemyelomaatdifferentstagesofthedisease AT vtmanchuk characteristicsofneutrophilchemiluminescenceinpatientswithtypegmultiplemyelomaatdifferentstagesofthedisease AT yunagilova characteristicsofneutrophilchemiluminescenceinpatientswithtypegmultiplemyelomaatdifferentstagesofthedisease
_version_	1718422432333692928

CHARACTERISTICS OF NEUTROPHIL CHEMILUMINESCENCE IN PATIENTS WITH TYPE G MULTIPLE MYELOMA AT DIFFERENT STAGES OF THE DISEASE

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