Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP <sup>C</sup> and Other Host-Specific Factors

Prion propagation can be interfered with by the expression of a second prion protein in the host. In the present study, we investigated prion propagation in a host expressing two different prion protein genes.

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Auteurs principaux: Juan Carlos Espinosa, Olivier Andreoletti, Alba Marín-Moreno, Severine Lugan, Patricia Aguilar-Calvo, Hervé Cassard, Patricia Lorenzo, Jean-Yves Douet, Ana Villa-Díaz, Naima Aron, Irene Prieto, Alvina Huor, Juan María Torres
Format: article
Langue:EN
Publié: American Society for Microbiology 2021
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Accès en ligne:https://doaj.org/article/864be9f0adbd4cde9faed67640c7b37f
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Résumé:Prion propagation can be interfered with by the expression of a second prion protein in the host. In the present study, we investigated prion propagation in a host expressing two different prion protein genes.