Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

In previous studies the authors discovered that miR-214 inhibits osteoblastic bone formation. Here they extend on these findings, using ovariectomized mice and samples from patients with bone fractures, to show that miR-214 is a mediator of osteoclast-osteoblast crosstalk.

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Autores principales:	Defang Li, Jin Liu, Baosheng Guo, Chao Liang, Lei Dang, Cheng Lu, Xiaojuan He, Hilda Yeuk-Siu Cheung, Liang Xu, Changwei Lu, Bing He, Biao Liu, Atik Badshah Shaikh, Fangfei Li, Luyao Wang, Zhijun Yang, Doris Wai-Ting Au, Songlin Peng, Zongkang Zhang, Bao-Ting Zhang, Xiaohua Pan, Airong Qian, Peng Shang, Lianbo Xiao, Baohong Jiang, Chris Kong-Chu Wong, Jiake Xu, Zhaoxiang Bian, Zicai Liang, De-an Guo, Hailong Zhu, Weihong Tan, Aiping Lu, Ge Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/864cd3b1e85c4239be137a2987e2ded7
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spelling	oai:doaj.org-article:864cd3b1e85c4239be137a2987e2ded72021-12-02T15:33:49ZOsteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation10.1038/ncomms108722041-1723https://doaj.org/article/864cd3b1e85c4239be137a2987e2ded72016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10872https://doaj.org/toc/2041-1723In previous studies the authors discovered that miR-214 inhibits osteoblastic bone formation. Here they extend on these findings, using ovariectomized mice and samples from patients with bone fractures, to show that miR-214 is a mediator of osteoclast-osteoblast crosstalk.Defang LiJin LiuBaosheng GuoChao LiangLei DangCheng LuXiaojuan HeHilda Yeuk-Siu CheungLiang XuChangwei LuBing HeBiao LiuAtik Badshah ShaikhFangfei LiLuyao WangZhijun YangDoris Wai-Ting AuSonglin PengZongkang ZhangBao-Ting ZhangXiaohua PanAirong QianPeng ShangLianbo XiaoBaohong JiangChris Kong-Chu WongJiake XuZhaoxiang BianZicai LiangDe-an GuoHailong ZhuWeihong TanAiping LuGe ZhangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Defang Li Jin Liu Baosheng Guo Chao Liang Lei Dang Cheng Lu Xiaojuan He Hilda Yeuk-Siu Cheung Liang Xu Changwei Lu Bing He Biao Liu Atik Badshah Shaikh Fangfei Li Luyao Wang Zhijun Yang Doris Wai-Ting Au Songlin Peng Zongkang Zhang Bao-Ting Zhang Xiaohua Pan Airong Qian Peng Shang Lianbo Xiao Baohong Jiang Chris Kong-Chu Wong Jiake Xu Zhaoxiang Bian Zicai Liang De-an Guo Hailong Zhu Weihong Tan Aiping Lu Ge Zhang Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
description	In previous studies the authors discovered that miR-214 inhibits osteoblastic bone formation. Here they extend on these findings, using ovariectomized mice and samples from patients with bone fractures, to show that miR-214 is a mediator of osteoclast-osteoblast crosstalk.
format	article
author	Defang Li Jin Liu Baosheng Guo Chao Liang Lei Dang Cheng Lu Xiaojuan He Hilda Yeuk-Siu Cheung Liang Xu Changwei Lu Bing He Biao Liu Atik Badshah Shaikh Fangfei Li Luyao Wang Zhijun Yang Doris Wai-Ting Au Songlin Peng Zongkang Zhang Bao-Ting Zhang Xiaohua Pan Airong Qian Peng Shang Lianbo Xiao Baohong Jiang Chris Kong-Chu Wong Jiake Xu Zhaoxiang Bian Zicai Liang De-an Guo Hailong Zhu Weihong Tan Aiping Lu Ge Zhang
author_facet	Defang Li Jin Liu Baosheng Guo Chao Liang Lei Dang Cheng Lu Xiaojuan He Hilda Yeuk-Siu Cheung Liang Xu Changwei Lu Bing He Biao Liu Atik Badshah Shaikh Fangfei Li Luyao Wang Zhijun Yang Doris Wai-Ting Au Songlin Peng Zongkang Zhang Bao-Ting Zhang Xiaohua Pan Airong Qian Peng Shang Lianbo Xiao Baohong Jiang Chris Kong-Chu Wong Jiake Xu Zhaoxiang Bian Zicai Liang De-an Guo Hailong Zhu Weihong Tan Aiping Lu Ge Zhang
author_sort	Defang Li
title	Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
title_short	Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
title_full	Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
title_fullStr	Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
title_full_unstemmed	Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
title_sort	osteoclast-derived exosomal mir-214-3p inhibits osteoblastic bone formation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/864cd3b1e85c4239be137a2987e2ded7
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Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

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