Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration

Abstract The design of transplantable scaffolds for tissue regeneration requires gaining precise control of topographical properties. Here, we propose a methodology to fabricate hierarchical multiscale scaffolds with controlled hydrophilic and hydrophobic properties by employing capillary force lith...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Woochan Kim, Yonghyun Gwon, Yang-Kyung Kim, Sunho Park, Sung-Ju Kang, Hyeng-Kyu Park, Myung-Sun Kim, Jangho Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/864db99f6bf64688a8caf738df331207
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:864db99f6bf64688a8caf738df331207
record_format	dspace
spelling	oai:doaj.org-article:864db99f6bf64688a8caf738df3312072021-12-02T14:55:10ZPlasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration10.1038/s41536-021-00162-y2057-3995https://doaj.org/article/864db99f6bf64688a8caf738df3312072021-09-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00162-yhttps://doaj.org/toc/2057-3995Abstract The design of transplantable scaffolds for tissue regeneration requires gaining precise control of topographical properties. Here, we propose a methodology to fabricate hierarchical multiscale scaffolds with controlled hydrophilic and hydrophobic properties by employing capillary force lithography in combination with plasma modification. Using our method, we fabricated biodegradable biomaterial (i.e., polycaprolactone (PCL))-based nitrogen gas (N-FN) and oxygen gas plasma-assisted flexible multiscale nanotopographic (O-FMN) patches with natural extracellular matrix-like hierarchical structures along with flexible and controlled hydrophilic properties. In response to multiscale nanotopographic and chemically modified surface cues, the proliferation and osteogenic mineralization of cells were significantly promoted. Furthermore, the O-FMN patch enhanced regeneration of the mineralized fibrocartilage tissue of the tendon–bone interface and the calvarial bone tissue in vivo in rat models. Overall, the PCL-based O-FMN patches could accelerate soft- and hard-tissue regeneration. Thus, our proposed methodology was confirmed as an efficient approach for the design and manipulation of scaffolds having a multiscale topography with controlled hydrophilic property.Woochan KimYonghyun GwonYang-Kyung KimSunho ParkSung-Ju KangHyeng-Kyu ParkMyung-Sun KimJangho KimNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Woochan Kim Yonghyun Gwon Yang-Kyung Kim Sunho Park Sung-Ju Kang Hyeng-Kyu Park Myung-Sun Kim Jangho Kim Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
description	Abstract The design of transplantable scaffolds for tissue regeneration requires gaining precise control of topographical properties. Here, we propose a methodology to fabricate hierarchical multiscale scaffolds with controlled hydrophilic and hydrophobic properties by employing capillary force lithography in combination with plasma modification. Using our method, we fabricated biodegradable biomaterial (i.e., polycaprolactone (PCL))-based nitrogen gas (N-FN) and oxygen gas plasma-assisted flexible multiscale nanotopographic (O-FMN) patches with natural extracellular matrix-like hierarchical structures along with flexible and controlled hydrophilic properties. In response to multiscale nanotopographic and chemically modified surface cues, the proliferation and osteogenic mineralization of cells were significantly promoted. Furthermore, the O-FMN patch enhanced regeneration of the mineralized fibrocartilage tissue of the tendon–bone interface and the calvarial bone tissue in vivo in rat models. Overall, the PCL-based O-FMN patches could accelerate soft- and hard-tissue regeneration. Thus, our proposed methodology was confirmed as an efficient approach for the design and manipulation of scaffolds having a multiscale topography with controlled hydrophilic property.
format	article
author	Woochan Kim Yonghyun Gwon Yang-Kyung Kim Sunho Park Sung-Ju Kang Hyeng-Kyu Park Myung-Sun Kim Jangho Kim
author_facet	Woochan Kim Yonghyun Gwon Yang-Kyung Kim Sunho Park Sung-Ju Kang Hyeng-Kyu Park Myung-Sun Kim Jangho Kim
author_sort	Woochan Kim
title	Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
title_short	Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
title_full	Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
title_fullStr	Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
title_full_unstemmed	Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
title_sort	plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/864db99f6bf64688a8caf738df331207
work_keys_str_mv	AT woochankim plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration AT yonghyungwon plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration AT yangkyungkim plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration AT sunhopark plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration AT sungjukang plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration AT hyengkyupark plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration AT myungsunkim plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration AT janghokim plasmaassistedmultiscaletopographicscaffoldsforsoftandhardtissueregeneration
_version_	1718389334102507520

Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration

Ejemplares similares