Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid di...

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Autores principales:	Marco L. Hennrich, Natalie Romanov, Patrick Horn, Samira Jaeger, Volker Eckstein, Violetta Steeples, Fei Ye, Ximing Ding, Laura Poisa-Beiro, Mang Ching Lai, Benjamin Lang, Jacqueline Boultwood, Thomas Luft, Judith B. Zaugg, Andrea Pellagatti, Peer Bork, Patrick Aloy, Anne-Claude Gavin, Anthony D. Ho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86524845718d4cb59745f4c377ff0da5
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spelling	oai:doaj.org-article:86524845718d4cb59745f4c377ff0da52021-12-02T14:40:54ZCell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline10.1038/s41467-018-06353-42041-1723https://doaj.org/article/86524845718d4cb59745f4c377ff0da52018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06353-4https://doaj.org/toc/2041-1723Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation.Marco L. HennrichNatalie RomanovPatrick HornSamira JaegerVolker EcksteinVioletta SteeplesFei YeXiming DingLaura Poisa-BeiroMang Ching LaiBenjamin LangJacqueline BoultwoodThomas LuftJudith B. ZauggAndrea PellagattiPeer BorkPatrick AloyAnne-Claude GavinAnthony D. HoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco L. Hennrich Natalie Romanov Patrick Horn Samira Jaeger Volker Eckstein Violetta Steeples Fei Ye Ximing Ding Laura Poisa-Beiro Mang Ching Lai Benjamin Lang Jacqueline Boultwood Thomas Luft Judith B. Zaugg Andrea Pellagatti Peer Bork Patrick Aloy Anne-Claude Gavin Anthony D. Ho Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
description	Ageing causes an inability to replace damaged tissue. Here, the authors perform proteomics analyses of human haematopoietic stem cells and other cells in the bone marrow niche at different ages and show changes in central carbon metabolism, reduced bone marrow niche function, and enhanced myeloid differentiation.
format	article
author	Marco L. Hennrich Natalie Romanov Patrick Horn Samira Jaeger Volker Eckstein Violetta Steeples Fei Ye Ximing Ding Laura Poisa-Beiro Mang Ching Lai Benjamin Lang Jacqueline Boultwood Thomas Luft Judith B. Zaugg Andrea Pellagatti Peer Bork Patrick Aloy Anne-Claude Gavin Anthony D. Ho
author_facet	Marco L. Hennrich Natalie Romanov Patrick Horn Samira Jaeger Volker Eckstein Violetta Steeples Fei Ye Ximing Ding Laura Poisa-Beiro Mang Ching Lai Benjamin Lang Jacqueline Boultwood Thomas Luft Judith B. Zaugg Andrea Pellagatti Peer Bork Patrick Aloy Anne-Claude Gavin Anthony D. Ho
author_sort	Marco L. Hennrich
title	Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
title_short	Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
title_full	Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
title_fullStr	Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
title_full_unstemmed	Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
title_sort	cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/86524845718d4cb59745f4c377ff0da5
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Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline

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