Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries

High-throughput assays for TCR specificity are a bottleneck in understanding T cell immunity and harnessing it for medicine. Here the authors develop a functional screening method to identify T cell specificity in the natural context of peptide-MHC presentation, enabling detection of physiologically...

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Autores principales:	Govinda Sharma, Craig M. Rive, Robert A. Holt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8658bff681884e7d8e541ee31a773af5
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spelling	oai:doaj.org-article:8658bff681884e7d8e541ee31a773af52021-12-02T16:58:27ZRapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries10.1038/s41467-019-12444-72041-1723https://doaj.org/article/8658bff681884e7d8e541ee31a773af52019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12444-7https://doaj.org/toc/2041-1723High-throughput assays for TCR specificity are a bottleneck in understanding T cell immunity and harnessing it for medicine. Here the authors develop a functional screening method to identify T cell specificity in the natural context of peptide-MHC presentation, enabling detection of physiologically relevant T cell antigens from large libraries of peptide-coding sequences.Govinda SharmaCraig M. RiveRobert A. HoltNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Govinda Sharma Craig M. Rive Robert A. Holt Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries
description	High-throughput assays for TCR specificity are a bottleneck in understanding T cell immunity and harnessing it for medicine. Here the authors develop a functional screening method to identify T cell specificity in the natural context of peptide-MHC presentation, enabling detection of physiologically relevant T cell antigens from large libraries of peptide-coding sequences.
format	article
author	Govinda Sharma Craig M. Rive Robert A. Holt
author_facet	Govinda Sharma Craig M. Rive Robert A. Holt
author_sort	Govinda Sharma
title	Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries
title_short	Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries
title_full	Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries
title_fullStr	Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries
title_full_unstemmed	Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries
title_sort	rapid selection and identification of functional cd8+ t cell epitopes from large peptide-coding libraries
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8658bff681884e7d8e541ee31a773af5
work_keys_str_mv	AT govindasharma rapidselectionandidentificationoffunctionalcd8tcellepitopesfromlargepeptidecodinglibraries AT craigmrive rapidselectionandidentificationoffunctionalcd8tcellepitopesfromlargepeptidecodinglibraries AT robertaholt rapidselectionandidentificationoffunctionalcd8tcellepitopesfromlargepeptidecodinglibraries
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Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries

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