Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons

Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons

Long noncoding RNAs (lncRNAs) are known to regulate the DNA damage response (DDR), however their role in the brain is less well studied. Here, the authors demonstrate a neuron-specific role for Brain Specific DNA-damage Related lncRNA1 (BS-DRL1) and show BS-DRL1 modulates DDR by interacting with HMG...

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Autores principales: Min-Min Lou, Xiao-Qiang Tang, Guang-Ming Wang, Jia He, Fang Luo, Ming-Feng Guan, Fei Wang, Huan Zou, Jun-Ying Wang, Qun Zhang, Ming-Jian Xu, Qi-Li Shi, Li-Bing Shen, Guo-Ming Ma, Yi Wu, Yao-Yang Zhang, Ai-bin Liang, Ting-Hua Wang, Liu-Lin Xiong, Jian Wang, Jun Xu, Wen-Yuan Wang
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/865a1ae8f53243eeaebf8820e40c99bb
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spelling oai:doaj.org-article:865a1ae8f53243eeaebf8820e40c99bb2021-12-02T18:18:35ZLong noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons10.1038/s41467-021-24236-z2041-1723https://doaj.org/article/865a1ae8f53243eeaebf8820e40c99bb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24236-zhttps://doaj.org/toc/2041-1723Long noncoding RNAs (lncRNAs) are known to regulate the DNA damage response (DDR), however their role in the brain is less well studied. Here, the authors demonstrate a neuron-specific role for Brain Specific DNA-damage Related lncRNA1 (BS-DRL1) and show BS-DRL1 modulates DDR by interacting with HMGB1 in a cell-type specific manner.Min-Min LouXiao-Qiang TangGuang-Ming WangJia HeFang LuoMing-Feng GuanFei WangHuan ZouJun-Ying WangQun ZhangMing-Jian XuQi-Li ShiLi-Bing ShenGuo-Ming MaYi WuYao-Yang ZhangAi-bin LiangTing-Hua WangLiu-Lin XiongJian WangJun XuWen-Yuan WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Min-Min Lou
Xiao-Qiang Tang
Guang-Ming Wang
Jia He
Fang Luo
Ming-Feng Guan
Fei Wang
Huan Zou
Jun-Ying Wang
Qun Zhang
Ming-Jian Xu
Qi-Li Shi
Li-Bing Shen
Guo-Ming Ma
Yi Wu
Yao-Yang Zhang
Ai-bin Liang
Ting-Hua Wang
Liu-Lin Xiong
Jian Wang
Jun Xu
Wen-Yuan Wang
Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
description Long noncoding RNAs (lncRNAs) are known to regulate the DNA damage response (DDR), however their role in the brain is less well studied. Here, the authors demonstrate a neuron-specific role for Brain Specific DNA-damage Related lncRNA1 (BS-DRL1) and show BS-DRL1 modulates DDR by interacting with HMGB1 in a cell-type specific manner.
format article
author Min-Min Lou
Xiao-Qiang Tang
Guang-Ming Wang
Jia He
Fang Luo
Ming-Feng Guan
Fei Wang
Huan Zou
Jun-Ying Wang
Qun Zhang
Ming-Jian Xu
Qi-Li Shi
Li-Bing Shen
Guo-Ming Ma
Yi Wu
Yao-Yang Zhang
Ai-bin Liang
Ting-Hua Wang
Liu-Lin Xiong
Jian Wang
Jun Xu
Wen-Yuan Wang
author_facet Min-Min Lou
Xiao-Qiang Tang
Guang-Ming Wang
Jia He
Fang Luo
Ming-Feng Guan
Fei Wang
Huan Zou
Jun-Ying Wang
Qun Zhang
Ming-Jian Xu
Qi-Li Shi
Li-Bing Shen
Guo-Ming Ma
Yi Wu
Yao-Yang Zhang
Ai-bin Liang
Ting-Hua Wang
Liu-Lin Xiong
Jian Wang
Jun Xu
Wen-Yuan Wang
author_sort Min-Min Lou
title Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
title_short Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
title_full Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
title_fullStr Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
title_full_unstemmed Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons
title_sort long noncoding rna bs-drl1 modulates the dna damage response and genome stability by interacting with hmgb1 in neurons
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/865a1ae8f53243eeaebf8820e40c99bb
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