Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies

Abstract Breast cancer (BC) is one of the most common types of cancer in women worldwide. Several factors including genetic and environmental have been linked with susceptibility to development of BC. Her2 is a transmembrane protein with tyrosine kinase activity, overexpressed in several cancers inc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	B. Madhu Krishna, Sanjib Chaudhary, Aditya K. Panda, Dipti Ranjan Mishra, Sandip K. Mishra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/865e4931f7524a5aa9521c6b4caa6a07
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:865e4931f7524a5aa9521c6b4caa6a07
record_format	dspace
spelling	oai:doaj.org-article:865e4931f7524a5aa9521c6b4caa6a072021-12-02T16:08:04ZHer2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies10.1038/s41598-018-25769-y2045-2322https://doaj.org/article/865e4931f7524a5aa9521c6b4caa6a072018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25769-yhttps://doaj.org/toc/2045-2322Abstract Breast cancer (BC) is one of the most common types of cancer in women worldwide. Several factors including genetic and environmental have been linked with susceptibility to development of BC. Her2 is a transmembrane protein with tyrosine kinase activity, overexpressed in several cancers including BC. Various studies in different populations have shown association of Her2 variants with susceptibility to BC, however these results were inconsistent, inconclusive and controversial. To obtain a common conclusive finding, we performed meta-analysis of 35 case-control studies reported earlier including 19, 220 cases and 22, 306 controls. We observed significant association of Her2 Ile655Val polymorphism with susceptibility to development of breast cancer (Overall allele Val vs Ile: OR = 1.130, 95% CI = 1.051–1.216, p = 0.001; Ile-Val vs Ile-Ile: OR = 1.100, 95% CI = 1.016–1.192, p = 0.019; Val-Val+Ile-Val vs Ile-Ile: OR = 1.127, 95% CI = 1.038–1.223, p = 0.004). Subgroup analysis indicated a significant association with susceptibility to breast cancer in African and Asian populations. However, such association was not observed in other ethnic groups. Our findings suggested that Her2 Ile655Val polymorphism is associated with breast cancer risk in overall, Asian and African populations, and can be used as diagnostic marker for BC.B. Madhu KrishnaSanjib ChaudharyAditya K. PandaDipti Ranjan MishraSandip K. MishraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-19 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. Madhu Krishna Sanjib Chaudhary Aditya K. Panda Dipti Ranjan Mishra Sandip K. Mishra Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
description	Abstract Breast cancer (BC) is one of the most common types of cancer in women worldwide. Several factors including genetic and environmental have been linked with susceptibility to development of BC. Her2 is a transmembrane protein with tyrosine kinase activity, overexpressed in several cancers including BC. Various studies in different populations have shown association of Her2 variants with susceptibility to BC, however these results were inconsistent, inconclusive and controversial. To obtain a common conclusive finding, we performed meta-analysis of 35 case-control studies reported earlier including 19, 220 cases and 22, 306 controls. We observed significant association of Her2 Ile655Val polymorphism with susceptibility to development of breast cancer (Overall allele Val vs Ile: OR = 1.130, 95% CI = 1.051–1.216, p = 0.001; Ile-Val vs Ile-Ile: OR = 1.100, 95% CI = 1.016–1.192, p = 0.019; Val-Val+Ile-Val vs Ile-Ile: OR = 1.127, 95% CI = 1.038–1.223, p = 0.004). Subgroup analysis indicated a significant association with susceptibility to breast cancer in African and Asian populations. However, such association was not observed in other ethnic groups. Our findings suggested that Her2 Ile655Val polymorphism is associated with breast cancer risk in overall, Asian and African populations, and can be used as diagnostic marker for BC.
format	article
author	B. Madhu Krishna Sanjib Chaudhary Aditya K. Panda Dipti Ranjan Mishra Sandip K. Mishra
author_facet	B. Madhu Krishna Sanjib Chaudhary Aditya K. Panda Dipti Ranjan Mishra Sandip K. Mishra
author_sort	B. Madhu Krishna
title	Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
title_short	Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
title_full	Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
title_fullStr	Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
title_full_unstemmed	Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
title_sort	her2 ile655val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/865e4931f7524a5aa9521c6b4caa6a07
work_keys_str_mv	AT bmadhukrishna her2ile655valpolymorphismanditsassociationwithbreastcancerriskanupdatedmetaanalysisofcasecontrolstudies AT sanjibchaudhary her2ile655valpolymorphismanditsassociationwithbreastcancerriskanupdatedmetaanalysisofcasecontrolstudies AT adityakpanda her2ile655valpolymorphismanditsassociationwithbreastcancerriskanupdatedmetaanalysisofcasecontrolstudies AT diptiranjanmishra her2ile655valpolymorphismanditsassociationwithbreastcancerriskanupdatedmetaanalysisofcasecontrolstudies AT sandipkmishra her2ile655valpolymorphismanditsassociationwithbreastcancerriskanupdatedmetaanalysisofcasecontrolstudies
_version_	1718384668820111360

Her2 Ile655Val polymorphism and its association with breast cancer risk: an updated meta-analysis of case-control studies

Ejemplares similares