Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-pre...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shan He, Yongnian Liu, Lijun Meng, Hongxing Sun, Ying Wang, Yun Ji, Janaki Purushe, Pan Chen, Changhong Li, Jozef Madzo, Jean-Pierre Issa, Jonathan Soboloff, Ran Reshef, Bethany Moore, Luca Gattinoni, Yi Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/865ed17d49994e7abe49c981111342a5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:865ed17d49994e7abe49c981111342a5
record_format	dspace
spelling	oai:doaj.org-article:865ed17d49994e7abe49c981111342a52021-12-02T14:42:04ZEzh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity10.1038/s41467-017-02187-82041-1723https://doaj.org/article/865ed17d49994e7abe49c981111342a52017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02187-8https://doaj.org/toc/2041-1723During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.Shan HeYongnian LiuLijun MengHongxing SunYing WangYun JiJanaki PurushePan ChenChanghong LiJozef MadzoJean-Pierre IssaJonathan SoboloffRan ReshefBethany MooreLuca GattinoniYi ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shan He Yongnian Liu Lijun Meng Hongxing Sun Ying Wang Yun Ji Janaki Purushe Pan Chen Changhong Li Jozef Madzo Jean-Pierre Issa Jonathan Soboloff Ran Reshef Bethany Moore Luca Gattinoni Yi Zhang Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
description	During an immune response naive CD8+ T cells can differentiate into either effector or memory T cells. Here the authors show that Akt-mediated phosphorylation of the epigenetic regulator Ezh2 is critical for the generation of an anti-tumor CD8 T cell response and promotes the expansion of memory-precursors.
format	article
author	Shan He Yongnian Liu Lijun Meng Hongxing Sun Ying Wang Yun Ji Janaki Purushe Pan Chen Changhong Li Jozef Madzo Jean-Pierre Issa Jonathan Soboloff Ran Reshef Bethany Moore Luca Gattinoni Yi Zhang
author_facet	Shan He Yongnian Liu Lijun Meng Hongxing Sun Ying Wang Yun Ji Janaki Purushe Pan Chen Changhong Li Jozef Madzo Jean-Pierre Issa Jonathan Soboloff Ran Reshef Bethany Moore Luca Gattinoni Yi Zhang
author_sort	Shan He
title	Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
title_short	Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
title_full	Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
title_fullStr	Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
title_full_unstemmed	Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity
title_sort	ezh2 phosphorylation state determines its capacity to maintain cd8+ t memory precursors for antitumor immunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/865ed17d49994e7abe49c981111342a5
work_keys_str_mv	AT shanhe ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT yongnianliu ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT lijunmeng ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT hongxingsun ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT yingwang ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT yunji ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT janakipurushe ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT panchen ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT changhongli ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT jozefmadzo ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT jeanpierreissa ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT jonathansoboloff ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT ranreshef ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT bethanymoore ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT lucagattinoni ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity AT yizhang ezh2phosphorylationstatedeterminesitscapacitytomaintaincd8tmemoryprecursorsforantitumorimmunity
_version_	1718389820350267392

Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

Ejemplares similares