Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis

Function of the mature central nervous system (CNS) requires a substantial proportion of the body’s energy consumption. During development, the CNS anlage must maintain its structure and perform stage-specific functions as it proceeds through discrete developmental stages. While key extrinsic signal...

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Autores principales:	Ryann M. Fame, Maria K. Lehtinen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	forebrain neurulation corticogenesis metabolism mitochondria development Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/86605917b7064147a0d872815a85a1da
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id	oai:doaj.org-article:86605917b7064147a0d872815a85a1da
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spelling	oai:doaj.org-article:86605917b7064147a0d872815a85a1da2021-11-30T13:25:39ZMitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis2296-634X10.3389/fcell.2021.780207https://doaj.org/article/86605917b7064147a0d872815a85a1da2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.780207/fullhttps://doaj.org/toc/2296-634XFunction of the mature central nervous system (CNS) requires a substantial proportion of the body’s energy consumption. During development, the CNS anlage must maintain its structure and perform stage-specific functions as it proceeds through discrete developmental stages. While key extrinsic signals and internal transcriptional controls over these processes are well appreciated, metabolic and mitochondrial states are also critical to appropriate forebrain development. Specifically, metabolic state, mitochondrial function, and mitochondrial dynamics/localization play critical roles in neurulation and CNS progenitor specification, progenitor proliferation and survival, neurogenesis, neural migration, and neurite outgrowth and synaptogenesis. With the goal of integrating neurodevelopmental biologists and mitochondrial specialists, this review synthesizes data from disparate models and processes to compile and highlight key roles of mitochondria in the early development of the CNS with specific focus on forebrain development and corticogenesis.Ryann M. FameMaria K. LehtinenFrontiers Media S.A.articleforebrainneurulationcorticogenesismetabolismmitochondriadevelopmentBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	forebrain neurulation corticogenesis metabolism mitochondria development Biology (General) QH301-705.5
spellingShingle	forebrain neurulation corticogenesis metabolism mitochondria development Biology (General) QH301-705.5 Ryann M. Fame Maria K. Lehtinen Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis
description	Function of the mature central nervous system (CNS) requires a substantial proportion of the body’s energy consumption. During development, the CNS anlage must maintain its structure and perform stage-specific functions as it proceeds through discrete developmental stages. While key extrinsic signals and internal transcriptional controls over these processes are well appreciated, metabolic and mitochondrial states are also critical to appropriate forebrain development. Specifically, metabolic state, mitochondrial function, and mitochondrial dynamics/localization play critical roles in neurulation and CNS progenitor specification, progenitor proliferation and survival, neurogenesis, neural migration, and neurite outgrowth and synaptogenesis. With the goal of integrating neurodevelopmental biologists and mitochondrial specialists, this review synthesizes data from disparate models and processes to compile and highlight key roles of mitochondria in the early development of the CNS with specific focus on forebrain development and corticogenesis.
format	article
author	Ryann M. Fame Maria K. Lehtinen
author_facet	Ryann M. Fame Maria K. Lehtinen
author_sort	Ryann M. Fame
title	Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis
title_short	Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis
title_full	Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis
title_fullStr	Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis
title_full_unstemmed	Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis
title_sort	mitochondria in early forebrain development: from neurulation to mid-corticogenesis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/86605917b7064147a0d872815a85a1da
work_keys_str_mv	AT ryannmfame mitochondriainearlyforebraindevelopmentfromneurulationtomidcorticogenesis AT mariaklehtinen mitochondriainearlyforebraindevelopmentfromneurulationtomidcorticogenesis
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Mitochondria in Early Forebrain Development: From Neurulation to Mid-Corticogenesis

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