EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

The exosome is a ribonucleolytic complex that plays part in RNA processing and degradation. Here, the authors reveal an RNA clearance event in homologous recombination and show the function of EXOSC10, a component of the exosome, in the homeostasis of RNA molecules synthesized at DSB sites.

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Autores principales:	Judit Domingo-Prim, Martin Endara-Coll, Franziska Bonath, Sonia Jimeno, Rosario Prados-Carvajal, Marc R. Friedländer, Pablo Huertas, Neus Visa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8660cb7f19ec4cacaf434de3f58eee41
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spelling	oai:doaj.org-article:8660cb7f19ec4cacaf434de3f58eee412021-12-02T15:35:10ZEXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks10.1038/s41467-019-10153-92041-1723https://doaj.org/article/8660cb7f19ec4cacaf434de3f58eee412019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10153-9https://doaj.org/toc/2041-1723The exosome is a ribonucleolytic complex that plays part in RNA processing and degradation. Here, the authors reveal an RNA clearance event in homologous recombination and show the function of EXOSC10, a component of the exosome, in the homeostasis of RNA molecules synthesized at DSB sites.Judit Domingo-PrimMartin Endara-CollFranziska BonathSonia JimenoRosario Prados-CarvajalMarc R. FriedländerPablo HuertasNeus VisaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Judit Domingo-Prim Martin Endara-Coll Franziska Bonath Sonia Jimeno Rosario Prados-Carvajal Marc R. Friedländer Pablo Huertas Neus Visa EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
description	The exosome is a ribonucleolytic complex that plays part in RNA processing and degradation. Here, the authors reveal an RNA clearance event in homologous recombination and show the function of EXOSC10, a component of the exosome, in the homeostasis of RNA molecules synthesized at DSB sites.
format	article
author	Judit Domingo-Prim Martin Endara-Coll Franziska Bonath Sonia Jimeno Rosario Prados-Carvajal Marc R. Friedländer Pablo Huertas Neus Visa
author_facet	Judit Domingo-Prim Martin Endara-Coll Franziska Bonath Sonia Jimeno Rosario Prados-Carvajal Marc R. Friedländer Pablo Huertas Neus Visa
author_sort	Judit Domingo-Prim
title	EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
title_short	EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
title_full	EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
title_fullStr	EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
title_full_unstemmed	EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks
title_sort	exosc10 is required for rpa assembly and controlled dna end resection at dna double-strand breaks
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8660cb7f19ec4cacaf434de3f58eee41
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EXOSC10 is required for RPA assembly and controlled DNA end resection at DNA double-strand breaks

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