Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor

Abstract Tears are extracellular fluid secreted from the lacrimal gland (LG). Tears consist of a dynamic tri-layered film composed of secretions from the LG, Meibomian gland, and conjunctival goblet cells. The LG secretes the aqueous component of the tear, the Meibomian gland secretes the lipid comp...

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Autores principales:	Toshihiro Imada, Shigeru Nakamura, Ryuji Hisamura, Yusuke Izuta, Kai Jin, Masataka Ito, Naoki Kitamura, Kenji F. Tanaka, Masaru Mimura, Izumi Shibuya, Kazuo Tsubota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8662a0b15415419ab6535c6046909a18
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spelling	oai:doaj.org-article:8662a0b15415419ab6535c6046909a182021-12-02T12:30:52ZSerotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor10.1038/s41598-017-06022-42045-2322https://doaj.org/article/8662a0b15415419ab6535c6046909a182017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06022-4https://doaj.org/toc/2045-2322Abstract Tears are extracellular fluid secreted from the lacrimal gland (LG). Tears consist of a dynamic tri-layered film composed of secretions from the LG, Meibomian gland, and conjunctival goblet cells. The LG secretes the aqueous component of the tear, the Meibomian gland secretes the lipid component, and conjunctival goblet cells secrete mucin. The regulation of LG activity via the autonomic nervous system has been recognized as fundamental to maintaining aqueous tear flow. Here, we describe the role of a hormone, peripheral serotonin, in tear secretion. We found that blood serotonin concentration, changed by feeding a diet deprived of the serotonin precursor tryptophan, correlated with tear secretion, and that a sustained decrease in serotonin resulted in LG atrophy and autophagy. The combination of a decrease in serotonin with the interruption of autonomic neural stimuli to the LG preceded these alterations. Furthermore, we found that the serotonin type 3a receptor expressed in LG acinar cells is involved in tear secretion via intracellular calcium mobilization. Our findings demonstrate that hormonal regulation by serotonin, in cooperation with the autonomic nervous system, regulates tear secretion.Toshihiro ImadaShigeru NakamuraRyuji HisamuraYusuke IzutaKai JinMasataka ItoNaoki KitamuraKenji F. TanakaMasaru MimuraIzumi ShibuyaKazuo TsubotaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toshihiro Imada Shigeru Nakamura Ryuji Hisamura Yusuke Izuta Kai Jin Masataka Ito Naoki Kitamura Kenji F. Tanaka Masaru Mimura Izumi Shibuya Kazuo Tsubota Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor
description	Abstract Tears are extracellular fluid secreted from the lacrimal gland (LG). Tears consist of a dynamic tri-layered film composed of secretions from the LG, Meibomian gland, and conjunctival goblet cells. The LG secretes the aqueous component of the tear, the Meibomian gland secretes the lipid component, and conjunctival goblet cells secrete mucin. The regulation of LG activity via the autonomic nervous system has been recognized as fundamental to maintaining aqueous tear flow. Here, we describe the role of a hormone, peripheral serotonin, in tear secretion. We found that blood serotonin concentration, changed by feeding a diet deprived of the serotonin precursor tryptophan, correlated with tear secretion, and that a sustained decrease in serotonin resulted in LG atrophy and autophagy. The combination of a decrease in serotonin with the interruption of autonomic neural stimuli to the LG preceded these alterations. Furthermore, we found that the serotonin type 3a receptor expressed in LG acinar cells is involved in tear secretion via intracellular calcium mobilization. Our findings demonstrate that hormonal regulation by serotonin, in cooperation with the autonomic nervous system, regulates tear secretion.
format	article
author	Toshihiro Imada Shigeru Nakamura Ryuji Hisamura Yusuke Izuta Kai Jin Masataka Ito Naoki Kitamura Kenji F. Tanaka Masaru Mimura Izumi Shibuya Kazuo Tsubota
author_facet	Toshihiro Imada Shigeru Nakamura Ryuji Hisamura Yusuke Izuta Kai Jin Masataka Ito Naoki Kitamura Kenji F. Tanaka Masaru Mimura Izumi Shibuya Kazuo Tsubota
author_sort	Toshihiro Imada
title	Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor
title_short	Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor
title_full	Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor
title_fullStr	Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor
title_full_unstemmed	Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor
title_sort	serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8662a0b15415419ab6535c6046909a18
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Serotonin hormonally regulates lacrimal gland secretory function via the serotonin type 3a receptor

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