Contemporary Management of Secondary Mitral Regurgitation

Secondary mitral regurgitation (SMR) is a common occurrence in patients with heart failure with reduced ejection fraction. Moderate-severe or severe SMR is associated with increased mortality and hospitalisations from heart failure. Medical and cardiac resynchronisation therapies have been the only...

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Autores principales:	Kashish Goel, Colin M Barker, JoAnn Lindenfeld
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/86660e3d677343dcbbfa13e7747fbada
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spelling	oai:doaj.org-article:86660e3d677343dcbbfa13e7747fbada2021-12-04T16:02:47ZContemporary Management of Secondary Mitral Regurgitation10.15420/ecr.2019.081758-37641758-3756https://doaj.org/article/86660e3d677343dcbbfa13e7747fbada2020-05-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2019.08https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Secondary mitral regurgitation (SMR) is a common occurrence in patients with heart failure with reduced ejection fraction. Moderate-severe or severe SMR is associated with increased mortality and hospitalisations from heart failure. Medical and cardiac resynchronisation therapies have been the only treatments proven to improve prognosis in this patient population. The Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy (COAPT) and the Percutaneous Repair with the MitraClip Device for Severe Functional/Secondary Mitral Regurgitation (MITRA-FR) RCTs evaluated transcatheter mitral valve repair with MitraClip for treatment of SMR in addition to medical therapy and they had divergent results. The COAPT trial demonstrated that a reduction in SMR with MitraClip resulted in reduced mortality and heart failure hospitalisations along with improved symptoms and quality of life in appropriately selected patients. The MITRA-FR trial did not show any benefit from using MitraClip for patients with SMR. This article summarises the differences in these two trials and suggests a contemporary approach to the management of SMR.Kashish GoelColin M BarkerJoAnn LindenfeldRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 15, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Kashish Goel Colin M Barker JoAnn Lindenfeld Contemporary Management of Secondary Mitral Regurgitation
description	Secondary mitral regurgitation (SMR) is a common occurrence in patients with heart failure with reduced ejection fraction. Moderate-severe or severe SMR is associated with increased mortality and hospitalisations from heart failure. Medical and cardiac resynchronisation therapies have been the only treatments proven to improve prognosis in this patient population. The Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy (COAPT) and the Percutaneous Repair with the MitraClip Device for Severe Functional/Secondary Mitral Regurgitation (MITRA-FR) RCTs evaluated transcatheter mitral valve repair with MitraClip for treatment of SMR in addition to medical therapy and they had divergent results. The COAPT trial demonstrated that a reduction in SMR with MitraClip resulted in reduced mortality and heart failure hospitalisations along with improved symptoms and quality of life in appropriately selected patients. The MITRA-FR trial did not show any benefit from using MitraClip for patients with SMR. This article summarises the differences in these two trials and suggests a contemporary approach to the management of SMR.
format	article
author	Kashish Goel Colin M Barker JoAnn Lindenfeld
author_facet	Kashish Goel Colin M Barker JoAnn Lindenfeld
author_sort	Kashish Goel
title	Contemporary Management of Secondary Mitral Regurgitation
title_short	Contemporary Management of Secondary Mitral Regurgitation
title_full	Contemporary Management of Secondary Mitral Regurgitation
title_fullStr	Contemporary Management of Secondary Mitral Regurgitation
title_full_unstemmed	Contemporary Management of Secondary Mitral Regurgitation
title_sort	contemporary management of secondary mitral regurgitation
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/86660e3d677343dcbbfa13e7747fbada
work_keys_str_mv	AT kashishgoel contemporarymanagementofsecondarymitralregurgitation AT colinmbarker contemporarymanagementofsecondarymitralregurgitation AT joannlindenfeld contemporarymanagementofsecondarymitralregurgitation
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Contemporary Management of Secondary Mitral Regurgitation

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