Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss

Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice.

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Detalles Bibliográficos
Autores principales:	Marco Quarta, Melinda Cromie, Robert Chacon, Justin Blonigan, Victor Garcia, Igor Akimenko, Mark Hamer, Patrick Paine, Merel Stok, Joseph B. Shrager, Thomas A. Rando
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/866687b376184d498404013b22fd5a49
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spelling	oai:doaj.org-article:866687b376184d498404013b22fd5a492021-12-02T15:38:44ZBioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss10.1038/ncomms156132041-1723https://doaj.org/article/866687b376184d498404013b22fd5a492017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15613https://doaj.org/toc/2041-1723Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice.Marco QuartaMelinda CromieRobert ChaconJustin BloniganVictor GarciaIgor AkimenkoMark HamerPatrick PaineMerel StokJoseph B. ShragerThomas A. RandoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco Quarta Melinda Cromie Robert Chacon Justin Blonigan Victor Garcia Igor Akimenko Mark Hamer Patrick Paine Merel Stok Joseph B. Shrager Thomas A. Rando Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
description	Volumetric muscle loss leads to functional muscle impairment, and current stem cell-based treatments show limited efficacy. Here, the authors generate a stem cell scaffold, implant it in mice, and show that an exercise regimen enhances innervation and restoration of muscle function in mice.
format	article
author	Marco Quarta Melinda Cromie Robert Chacon Justin Blonigan Victor Garcia Igor Akimenko Mark Hamer Patrick Paine Merel Stok Joseph B. Shrager Thomas A. Rando
author_facet	Marco Quarta Melinda Cromie Robert Chacon Justin Blonigan Victor Garcia Igor Akimenko Mark Hamer Patrick Paine Merel Stok Joseph B. Shrager Thomas A. Rando
author_sort	Marco Quarta
title	Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
title_short	Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
title_full	Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
title_fullStr	Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
title_full_unstemmed	Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
title_sort	bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/866687b376184d498404013b22fd5a49
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Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss

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