Loss of RBPj in postnatal excitatory neurons does not cause neurodegeneration or memory impairments in aged mice.
Previous studies suggest that loss of γ-secretase activity in postnatal mouse brains causes age-dependent memory impairment and neurodegeneration. Due to the diverse array of γ-secretase substrates, it remains to be demonstrated whether loss of cleavage of any specific substrate(s) is responsible fo...
Guardado en:
Autores principales: | Chihiro Sato, Mustafa Turkoz, Joshua T Dearborn, David F Wozniak, Raphael Kopan, Matthew R Hass |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2012
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Materias: | |
Acceso en línea: | https://doaj.org/article/866e48f701074e758bca789c28719da6 |
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