Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.

Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.

<h4>Objective</h4>Prospectively assess the performance of diffusion-weighted magnetic resonance imaging (DW-MRI) for differentiation of central lung cancer from atelectasis.<h4>Materials and methods</h4>38 consecutive lung cancer patients (26 males, 12 females; age range: 28-...

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Autores principales: Rui-Meng Yang, Long Li, Xin-Hua Wei, Yong-Mei Guo, Yun-Hai Huang, Li-Sha Lai, A-Mei Chen, Guo-Shun Liu, Wei-Feng Xiong, Liang-Ping Luo, Xin-Qing Jiang
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/86702c8333474060a0ce4e4b71379337
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spelling oai:doaj.org-article:86702c8333474060a0ce4e4b713793372021-11-18T07:50:38ZDifferentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.1932-620310.1371/journal.pone.0060279https://doaj.org/article/86702c8333474060a0ce4e4b713793372013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23593186/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Prospectively assess the performance of diffusion-weighted magnetic resonance imaging (DW-MRI) for differentiation of central lung cancer from atelectasis.<h4>Materials and methods</h4>38 consecutive lung cancer patients (26 males, 12 females; age range: 28-71 years; mean age: 49 years) who were referred for thoracic MR imaging examinations were enrolled. MR examinations were performed using a 1.5-T clinical scanner and scanning sequences of T1WI, T2WI, and DWI. Cancers and atelectasis were measured by mapping of the apparent diffusion coefficients (ADCs) obtained with a b-value of 500 s/mm(2).<h4>Results</h4>PET/CT and DW-MR allowed differentiation of tumor and atelectasis in all 38 cases, but T2WI did not allow differentiation in 9 cases. Comparison of conventional T2WI and DW-MRI indicated a higher contrast noise ratio of the central lung carcinoma than the atelectasis by DW-MRI. ADC maps indicated significantly lower mean ADC in the central lung carcinoma than in the atelectasis (1.83±0.58 vs. 2.90±0.26 mm(2)/s, p<0.0001). ADC values of small cell lung carcinoma were significantly greater than those from squamous cell carcinoma and adenocarcinoma (p<0.0001 for both).<h4>Conclusions</h4>DW-MR imaging provides valuable information not obtained by conventional MR and may be useful for differentiation of central lung carcinoma from atelectasis. Future developments may allow DW-MR imaging to be used as an alternative to PET-CT in imaging of patients with lung cancer.Rui-Meng YangLong LiXin-Hua WeiYong-Mei GuoYun-Hai HuangLi-Sha LaiA-Mei ChenGuo-Shun LiuWei-Feng XiongLiang-Ping LuoXin-Qing JiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60279 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Rui-Meng Yang
Long Li
Xin-Hua Wei
Yong-Mei Guo
Yun-Hai Huang
Li-Sha Lai
A-Mei Chen
Guo-Shun Liu
Wei-Feng Xiong
Liang-Ping Luo
Xin-Qing Jiang
Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.
description <h4>Objective</h4>Prospectively assess the performance of diffusion-weighted magnetic resonance imaging (DW-MRI) for differentiation of central lung cancer from atelectasis.<h4>Materials and methods</h4>38 consecutive lung cancer patients (26 males, 12 females; age range: 28-71 years; mean age: 49 years) who were referred for thoracic MR imaging examinations were enrolled. MR examinations were performed using a 1.5-T clinical scanner and scanning sequences of T1WI, T2WI, and DWI. Cancers and atelectasis were measured by mapping of the apparent diffusion coefficients (ADCs) obtained with a b-value of 500 s/mm(2).<h4>Results</h4>PET/CT and DW-MR allowed differentiation of tumor and atelectasis in all 38 cases, but T2WI did not allow differentiation in 9 cases. Comparison of conventional T2WI and DW-MRI indicated a higher contrast noise ratio of the central lung carcinoma than the atelectasis by DW-MRI. ADC maps indicated significantly lower mean ADC in the central lung carcinoma than in the atelectasis (1.83±0.58 vs. 2.90±0.26 mm(2)/s, p<0.0001). ADC values of small cell lung carcinoma were significantly greater than those from squamous cell carcinoma and adenocarcinoma (p<0.0001 for both).<h4>Conclusions</h4>DW-MR imaging provides valuable information not obtained by conventional MR and may be useful for differentiation of central lung carcinoma from atelectasis. Future developments may allow DW-MR imaging to be used as an alternative to PET-CT in imaging of patients with lung cancer.
format article
author Rui-Meng Yang
Long Li
Xin-Hua Wei
Yong-Mei Guo
Yun-Hai Huang
Li-Sha Lai
A-Mei Chen
Guo-Shun Liu
Wei-Feng Xiong
Liang-Ping Luo
Xin-Qing Jiang
author_facet Rui-Meng Yang
Long Li
Xin-Hua Wei
Yong-Mei Guo
Yun-Hai Huang
Li-Sha Lai
A-Mei Chen
Guo-Shun Liu
Wei-Feng Xiong
Liang-Ping Luo
Xin-Qing Jiang
author_sort Rui-Meng Yang
title Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.
title_short Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.
title_full Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.
title_fullStr Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.
title_full_unstemmed Differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted MRI with PET/CT.
title_sort differentiation of central lung cancer from atelectasis: comparison of diffusion-weighted mri with pet/ct.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/86702c8333474060a0ce4e4b71379337
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