MiR-424/503-mediated Rictor upregulation promotes tumor progression.

mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific component, contributes to tumor progression. Ricto...

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Autores principales:	Chitose Oneyama, Yoriko Kito, Rei Asai, Jun-ichiro Ikeda, Takuya Yoshida, Daisuke Okuzaki, Rie Kokuda, Kyoko Kakumoto, Ken-ichi Takayama, Satoshi Inoue, Eiichi Morii, Masato Okada
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8670d7cb97c449a39cb6314a7ccd8123
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id	oai:doaj.org-article:8670d7cb97c449a39cb6314a7ccd8123
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spelling	oai:doaj.org-article:8670d7cb97c449a39cb6314a7ccd81232021-11-18T08:47:18ZMiR-424/503-mediated Rictor upregulation promotes tumor progression.1932-620310.1371/journal.pone.0080300https://doaj.org/article/8670d7cb97c449a39cb6314a7ccd81232013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24244675/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific component, contributes to tumor progression. Rictor is upregulated via the repression of the miR-424/503 cluster in human prostate and colon cancer cell lines that harbor c-Src upregulation and in Src-transformed cells. The tumorigenicity and invasive activity of these cells were suppressed by re-expression of miR-424/503. Rictor upregulation promotes formation of mTORC2 and induces activation of mTORC2, resulting in promotion of tumor growth and invasion. Furthermore, downregulation of miR-424/503 is associated with Rictor upregulation in colon cancer tissues. These findings suggest that the miR-424/503-Rictor pathway plays a crucial role in tumor progression.Chitose OneyamaYoriko KitoRei AsaiJun-ichiro IkedaTakuya YoshidaDaisuke OkuzakiRie KokudaKyoko KakumotoKen-ichi TakayamaSatoshi InoueEiichi MoriiMasato OkadaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80300 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chitose Oneyama Yoriko Kito Rei Asai Jun-ichiro Ikeda Takuya Yoshida Daisuke Okuzaki Rie Kokuda Kyoko Kakumoto Ken-ichi Takayama Satoshi Inoue Eiichi Morii Masato Okada MiR-424/503-mediated Rictor upregulation promotes tumor progression.
description	mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific component, contributes to tumor progression. Rictor is upregulated via the repression of the miR-424/503 cluster in human prostate and colon cancer cell lines that harbor c-Src upregulation and in Src-transformed cells. The tumorigenicity and invasive activity of these cells were suppressed by re-expression of miR-424/503. Rictor upregulation promotes formation of mTORC2 and induces activation of mTORC2, resulting in promotion of tumor growth and invasion. Furthermore, downregulation of miR-424/503 is associated with Rictor upregulation in colon cancer tissues. These findings suggest that the miR-424/503-Rictor pathway plays a crucial role in tumor progression.
format	article
author	Chitose Oneyama Yoriko Kito Rei Asai Jun-ichiro Ikeda Takuya Yoshida Daisuke Okuzaki Rie Kokuda Kyoko Kakumoto Ken-ichi Takayama Satoshi Inoue Eiichi Morii Masato Okada
author_facet	Chitose Oneyama Yoriko Kito Rei Asai Jun-ichiro Ikeda Takuya Yoshida Daisuke Okuzaki Rie Kokuda Kyoko Kakumoto Ken-ichi Takayama Satoshi Inoue Eiichi Morii Masato Okada
author_sort	Chitose Oneyama
title	MiR-424/503-mediated Rictor upregulation promotes tumor progression.
title_short	MiR-424/503-mediated Rictor upregulation promotes tumor progression.
title_full	MiR-424/503-mediated Rictor upregulation promotes tumor progression.
title_fullStr	MiR-424/503-mediated Rictor upregulation promotes tumor progression.
title_full_unstemmed	MiR-424/503-mediated Rictor upregulation promotes tumor progression.
title_sort	mir-424/503-mediated rictor upregulation promotes tumor progression.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8670d7cb97c449a39cb6314a7ccd8123
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MiR-424/503-mediated Rictor upregulation promotes tumor progression.

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