MiR-424/503-mediated Rictor upregulation promotes tumor progression.

MiR-424/503-mediated Rictor upregulation promotes tumor progression.

mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific component, contributes to tumor progression. Ricto...

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Bibliographic Details
Main Authors: Chitose Oneyama, Yoriko Kito, Rei Asai, Jun-ichiro Ikeda, Takuya Yoshida, Daisuke Okuzaki, Rie Kokuda, Kyoko Kakumoto, Ken-ichi Takayama, Satoshi Inoue, Eiichi Morii, Masato Okada
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2013
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/8670d7cb97c449a39cb6314a7ccd8123
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https://doaj.org/article/8670d7cb97c449a39cb6314a7ccd8123

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