Role of N-acetyltransferase 2 gene polymorphism in the human pathology

Nowadays multiple heterogeneous chemicals affect the human body. They include drugs, household chemicals, dyes, food supplements and others. The human organism can modify, inactivate, and eliminate the chemicals by biotransformation enzymes. But it is well known that biotransformation can lead to to...

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Autores principales:	N. P. Peretolchina, I. V. Malov, I. Zh. Seminskiy
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	nat2 gene polymorphism xenobiotics biotransformation acetylation n-acetyltransferase human diseases toxification Science Q
Acceso en línea:	https://doaj.org/article/86714a1e8e2c46babe52944f62481fca
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spelling	oai:doaj.org-article:86714a1e8e2c46babe52944f62481fca2021-11-23T06:14:46ZRole of N-acetyltransferase 2 gene polymorphism in the human pathology2541-94202587-959610.29413/ABS.2021-6.5.4https://doaj.org/article/86714a1e8e2c46babe52944f62481fca2021-11-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/3027https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Nowadays multiple heterogeneous chemicals affect the human body. They include drugs, household chemicals, dyes, food supplements and others. The human organism can modify, inactivate, and eliminate the chemicals by biotransformation enzymes. But it is well known that biotransformation can lead to toxification phenomenon. Individuals differ from each other by the rate of chemical modification that promotes accumulation of toxins and carcinogens in some patients. An N-acetyltransferase 2 enzyme participates in the aromatic amines second phase metabolism. This work reviews the acetyltransferase gene polymorphism possible role in diseases development including drug-induced organs damage.Gene of acetyltransferase has polymorphisms associated with two haplotypes of fast and slow substrate acetylation. Gene alleles combine in three genotypes: fast, intermediate, and slow acetylators. Acetylation rate plays a significant role in side effects development during tuberculosis treatment and cancer pathogenesis. Recently, new data described the role of enzyme in development of non-infectious diseases in the human. Scientists consider that slow acetylation genotype in combination with high xenobiotic load result in accumulation of toxic substances able to damage cells.Therefore, acetyltransferase genotyping helps to reveal risk groups of cancer and non-infectious disease development and to prescribe more effective and safe doses of drugs.N. P. PeretolchinaI. V. MalovI. Zh. SeminskiyScientific Сentre for Family Health and Human Reproduction Problemsarticlenat2 gene polymorphismxenobiotics biotransformationacetylationn-acetyltransferasehuman diseasestoxificationScienceQRUActa Biomedica Scientifica, Vol 6, Iss 5, Pp 30-43 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	nat2 gene polymorphism xenobiotics biotransformation acetylation n-acetyltransferase human diseases toxification Science Q
spellingShingle	nat2 gene polymorphism xenobiotics biotransformation acetylation n-acetyltransferase human diseases toxification Science Q N. P. Peretolchina I. V. Malov I. Zh. Seminskiy Role of N-acetyltransferase 2 gene polymorphism in the human pathology
description	Nowadays multiple heterogeneous chemicals affect the human body. They include drugs, household chemicals, dyes, food supplements and others. The human organism can modify, inactivate, and eliminate the chemicals by biotransformation enzymes. But it is well known that biotransformation can lead to toxification phenomenon. Individuals differ from each other by the rate of chemical modification that promotes accumulation of toxins and carcinogens in some patients. An N-acetyltransferase 2 enzyme participates in the aromatic amines second phase metabolism. This work reviews the acetyltransferase gene polymorphism possible role in diseases development including drug-induced organs damage.Gene of acetyltransferase has polymorphisms associated with two haplotypes of fast and slow substrate acetylation. Gene alleles combine in three genotypes: fast, intermediate, and slow acetylators. Acetylation rate plays a significant role in side effects development during tuberculosis treatment and cancer pathogenesis. Recently, new data described the role of enzyme in development of non-infectious diseases in the human. Scientists consider that slow acetylation genotype in combination with high xenobiotic load result in accumulation of toxic substances able to damage cells.Therefore, acetyltransferase genotyping helps to reveal risk groups of cancer and non-infectious disease development and to prescribe more effective and safe doses of drugs.
format	article
author	N. P. Peretolchina I. V. Malov I. Zh. Seminskiy
author_facet	N. P. Peretolchina I. V. Malov I. Zh. Seminskiy
author_sort	N. P. Peretolchina
title	Role of N-acetyltransferase 2 gene polymorphism in the human pathology
title_short	Role of N-acetyltransferase 2 gene polymorphism in the human pathology
title_full	Role of N-acetyltransferase 2 gene polymorphism in the human pathology
title_fullStr	Role of N-acetyltransferase 2 gene polymorphism in the human pathology
title_full_unstemmed	Role of N-acetyltransferase 2 gene polymorphism in the human pathology
title_sort	role of n-acetyltransferase 2 gene polymorphism in the human pathology
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/86714a1e8e2c46babe52944f62481fca
work_keys_str_mv	AT npperetolchina roleofnacetyltransferase2genepolymorphisminthehumanpathology AT ivmalov roleofnacetyltransferase2genepolymorphisminthehumanpathology AT izhseminskiy roleofnacetyltransferase2genepolymorphisminthehumanpathology
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Role of N-acetyltransferase 2 gene polymorphism in the human pathology

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