A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

A rapid cellular response to interferons (IFNs) is critical for establishing antimicrobial immunity, but how cells switch from from homeostasis to IFN signaling is not fully understood. Here, the authors provide evidence that IFNs induce gene expression by alternating subunits of transcription facto...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ekaterini Platanitis, Duygu Demiroz, Anja Schneller, Katrin Fischer, Christophe Capelle, Markus Hartl, Thomas Gossenreiter, Mathias Müller, Maria Novatchkova, Thomas Decker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/8672899899844ee1b41b987824ab10f8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:8672899899844ee1b41b987824ab10f8
record_format dspace
spelling oai:doaj.org-article:8672899899844ee1b41b987824ab10f82021-12-02T16:57:11ZA molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription10.1038/s41467-019-10970-y2041-1723https://doaj.org/article/8672899899844ee1b41b987824ab10f82019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10970-yhttps://doaj.org/toc/2041-1723A rapid cellular response to interferons (IFNs) is critical for establishing antimicrobial immunity, but how cells switch from from homeostasis to IFN signaling is not fully understood. Here, the authors provide evidence that IFNs induce gene expression by alternating subunits of transcription factor ISGF3.Ekaterini PlatanitisDuygu DemirozAnja SchnellerKatrin FischerChristophe CapelleMarkus HartlThomas GossenreiterMathias MüllerMaria NovatchkovaThomas DeckerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ekaterini Platanitis
Duygu Demiroz
Anja Schneller
Katrin Fischer
Christophe Capelle
Markus Hartl
Thomas Gossenreiter
Mathias Müller
Maria Novatchkova
Thomas Decker
A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
description A rapid cellular response to interferons (IFNs) is critical for establishing antimicrobial immunity, but how cells switch from from homeostasis to IFN signaling is not fully understood. Here, the authors provide evidence that IFNs induce gene expression by alternating subunits of transcription factor ISGF3.
format article
author Ekaterini Platanitis
Duygu Demiroz
Anja Schneller
Katrin Fischer
Christophe Capelle
Markus Hartl
Thomas Gossenreiter
Mathias Müller
Maria Novatchkova
Thomas Decker
author_facet Ekaterini Platanitis
Duygu Demiroz
Anja Schneller
Katrin Fischer
Christophe Capelle
Markus Hartl
Thomas Gossenreiter
Mathias Müller
Maria Novatchkova
Thomas Decker
author_sort Ekaterini Platanitis
title A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
title_short A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
title_full A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
title_fullStr A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
title_full_unstemmed A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription
title_sort molecular switch from stat2-irf9 to isgf3 underlies interferon-induced gene transcription
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/8672899899844ee1b41b987824ab10f8
work_keys_str_mv AT ekateriniplatanitis amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT duygudemiroz amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT anjaschneller amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT katrinfischer amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT christophecapelle amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT markushartl amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT thomasgossenreiter amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT mathiasmuller amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT marianovatchkova amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT thomasdecker amolecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT ekateriniplatanitis molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT duygudemiroz molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT anjaschneller molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT katrinfischer molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT christophecapelle molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT markushartl molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT thomasgossenreiter molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT mathiasmuller molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT marianovatchkova molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
AT thomasdecker molecularswitchfromstat2irf9toisgf3underliesinterferoninducedgenetranscription
_version_ 1718382576651993088

Ejemplares similares