A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

A rapid cellular response to interferons (IFNs) is critical for establishing antimicrobial immunity, but how cells switch from from homeostasis to IFN signaling is not fully understood. Here, the authors provide evidence that IFNs induce gene expression by alternating subunits of transcription facto...

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Autores principales: Ekaterini Platanitis, Duygu Demiroz, Anja Schneller, Katrin Fischer, Christophe Capelle, Markus Hartl, Thomas Gossenreiter, Mathias Müller, Maria Novatchkova, Thomas Decker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/8672899899844ee1b41b987824ab10f8
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