Caveolin-1 as a pathophysiological factor and target in psoriasis

Abstract Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psoriasis. At the same time, the interfacial layers of t...

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Autores principales:	Ilja L. Kruglikov, Philipp E. Scherer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/8674ebd491174d1ba425479a6e78125a
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spelling	oai:doaj.org-article:8674ebd491174d1ba425479a6e78125a2021-12-02T13:41:46ZCaveolin-1 as a pathophysiological factor and target in psoriasis10.1038/s41514-019-0034-x2056-3973https://doaj.org/article/8674ebd491174d1ba425479a6e78125a2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41514-019-0034-xhttps://doaj.org/toc/2056-3973Abstract Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psoriasis. At the same time, the interfacial layers of the white adipose tissue (WAT) adjacent to psoriatic lesions demonstrate much higher stiffness, which also points to a modification of Cav-1 expression in this tissue. These processes are connected with each other and regulated via exosomal exchange. Here we discuss the role of Cav-1 expression in inflammatory and hyperproliferative processes and analyze the ways to provide spatially different modulation of Cav-1 expression in the skin and WAT. Such modulation can be induced by different pharmacological and physical factors. These include application of mechanical stress and supra-physiological temperatures. Cav-1 should therefore be considered as an important target in treatment of psoriasis.Ilja L. KruglikovPhilipp E. SchererNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 5, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Ilja L. Kruglikov Philipp E. Scherer Caveolin-1 as a pathophysiological factor and target in psoriasis
description	Abstract Low expression of caveolin-1 (Cav-1) is typical in psoriatic lesions and overexpression of Cav-1 leads to a reduction of inflammation and suppression of epidermal hyperproliferation, thus ameliorating these two well-known hallmarks of psoriasis. At the same time, the interfacial layers of the white adipose tissue (WAT) adjacent to psoriatic lesions demonstrate much higher stiffness, which also points to a modification of Cav-1 expression in this tissue. These processes are connected with each other and regulated via exosomal exchange. Here we discuss the role of Cav-1 expression in inflammatory and hyperproliferative processes and analyze the ways to provide spatially different modulation of Cav-1 expression in the skin and WAT. Such modulation can be induced by different pharmacological and physical factors. These include application of mechanical stress and supra-physiological temperatures. Cav-1 should therefore be considered as an important target in treatment of psoriasis.
format	article
author	Ilja L. Kruglikov Philipp E. Scherer
author_facet	Ilja L. Kruglikov Philipp E. Scherer
author_sort	Ilja L. Kruglikov
title	Caveolin-1 as a pathophysiological factor and target in psoriasis
title_short	Caveolin-1 as a pathophysiological factor and target in psoriasis
title_full	Caveolin-1 as a pathophysiological factor and target in psoriasis
title_fullStr	Caveolin-1 as a pathophysiological factor and target in psoriasis
title_full_unstemmed	Caveolin-1 as a pathophysiological factor and target in psoriasis
title_sort	caveolin-1 as a pathophysiological factor and target in psoriasis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8674ebd491174d1ba425479a6e78125a
work_keys_str_mv	AT iljalkruglikov caveolin1asapathophysiologicalfactorandtargetinpsoriasis AT philippescherer caveolin1asapathophysiologicalfactorandtargetinpsoriasis
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Caveolin-1 as a pathophysiological factor and target in psoriasis

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