Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects

Abstract To investigate the value of decomposed short-time digital volume pulse (DVP) signals in discerning systemic vascular anomaly in diabetic patients, demographic and anthropometric parameters, serum lipid profile, fasting blood glucose and glycated hemoglobin (HbA1c) levels were obtained from...

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Autores principales:	Hai-Cheng Wei, Ming-Xia Xiao, Hong-Yu Chen, Yun-Qin Li, Hsien-Tsai Wu, Cheuk-Kwan Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Hilbert-Huang Transformation (HHT) Digital Volume Pulse (DVP) Arterial Stiffness Instantaneous Frequency Ensemble Empirical Mode Decomposition (EEMD) Medicine R Science Q
Acceso en línea:	https://doaj.org/article/867a69e896aa44edbbccf0a240b642f0
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spelling	oai:doaj.org-article:867a69e896aa44edbbccf0a240b642f02021-12-02T15:07:46ZInstantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects10.1038/s41598-018-34091-62045-2322https://doaj.org/article/867a69e896aa44edbbccf0a240b642f02018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34091-6https://doaj.org/toc/2045-2322Abstract To investigate the value of decomposed short-time digital volume pulse (DVP) signals in discerning systemic vascular anomaly in diabetic patients, demographic and anthropometric parameters, serum lipid profile, fasting blood glucose and glycated hemoglobin (HbA1c) levels were obtained from 29 healthy adults (Group 1) and 29 age-matched type 2 diabetes mellitus patients (Group 2). Six-second DVP signals from right index finger acquired through photoplethysmography were decomposed using ensemble empirical mode decomposition. Using one intrinsic mode function (IMF5), stiffness index (SI) and instantaneous energy of maximal energy (fEmax) were obtained. Other indicators of arterial stiffness, including electrocardiogram-pulse wave velocity of foot (ECG-PWVfoot), crest time (CT) and crest time ratio (CTR), were obtained from the testing subjects for comparison. The mean body weight, body mass index, waist circumference, HbA1c and fasting blood sugar levels were higher in Group 2 than those in Group 1, whereas values of systolic and diastolic blood pressure were lower in Group 2 than those in Group 1. SI and fEmax were significantly higher in Group 2 than those in Group 1. Moreover, fEmax was positively associated with HbA1c concentration, CT and SI in Group 2 (p < 0.05) but not in Group 1. When all subjects were considered, fEmax was highly significantly associated with HbA1c and fasting blood sugar levels, and SI (all p < 0.001). After Hilbert-Huang transformation, short-time DVP signals could give significant information on arterial stiffness and vascular anomaly in diabetic patients.Hai-Cheng WeiMing-Xia XiaoHong-Yu ChenYun-Qin LiHsien-Tsai WuCheuk-Kwan SunNature PortfolioarticleHilbert-Huang Transformation (HHT)Digital Volume Pulse (DVP)Arterial StiffnessInstantaneous FrequencyEnsemble Empirical Mode Decomposition (EEMD)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hilbert-Huang Transformation (HHT) Digital Volume Pulse (DVP) Arterial Stiffness Instantaneous Frequency Ensemble Empirical Mode Decomposition (EEMD) Medicine R Science Q
spellingShingle	Hilbert-Huang Transformation (HHT) Digital Volume Pulse (DVP) Arterial Stiffness Instantaneous Frequency Ensemble Empirical Mode Decomposition (EEMD) Medicine R Science Q Hai-Cheng Wei Ming-Xia Xiao Hong-Yu Chen Yun-Qin Li Hsien-Tsai Wu Cheuk-Kwan Sun Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
description	Abstract To investigate the value of decomposed short-time digital volume pulse (DVP) signals in discerning systemic vascular anomaly in diabetic patients, demographic and anthropometric parameters, serum lipid profile, fasting blood glucose and glycated hemoglobin (HbA1c) levels were obtained from 29 healthy adults (Group 1) and 29 age-matched type 2 diabetes mellitus patients (Group 2). Six-second DVP signals from right index finger acquired through photoplethysmography were decomposed using ensemble empirical mode decomposition. Using one intrinsic mode function (IMF5), stiffness index (SI) and instantaneous energy of maximal energy (fEmax) were obtained. Other indicators of arterial stiffness, including electrocardiogram-pulse wave velocity of foot (ECG-PWVfoot), crest time (CT) and crest time ratio (CTR), were obtained from the testing subjects for comparison. The mean body weight, body mass index, waist circumference, HbA1c and fasting blood sugar levels were higher in Group 2 than those in Group 1, whereas values of systolic and diastolic blood pressure were lower in Group 2 than those in Group 1. SI and fEmax were significantly higher in Group 2 than those in Group 1. Moreover, fEmax was positively associated with HbA1c concentration, CT and SI in Group 2 (p < 0.05) but not in Group 1. When all subjects were considered, fEmax was highly significantly associated with HbA1c and fasting blood sugar levels, and SI (all p < 0.001). After Hilbert-Huang transformation, short-time DVP signals could give significant information on arterial stiffness and vascular anomaly in diabetic patients.
format	article
author	Hai-Cheng Wei Ming-Xia Xiao Hong-Yu Chen Yun-Qin Li Hsien-Tsai Wu Cheuk-Kwan Sun
author_facet	Hai-Cheng Wei Ming-Xia Xiao Hong-Yu Chen Yun-Qin Li Hsien-Tsai Wu Cheuk-Kwan Sun
author_sort	Hai-Cheng Wei
title	Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
title_short	Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
title_full	Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
title_fullStr	Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
title_full_unstemmed	Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
title_sort	instantaneous frequency from hilbert-huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/867a69e896aa44edbbccf0a240b642f0
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Instantaneous frequency from Hilbert-Huang transformation of digital volume pulse as indicator of diabetes and arterial stiffness in upper-middle-aged subjects

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