The Role of Circular RNAs in DNA Damage Response and Repair

Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs that are abundantly expressed in the cell. CircRNAs have the capacity to regulate gene expression by interacting with regulatory proteins and/or other classes of RNAs. While a vast number of circRNAs have been discovered, the major...

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Autores principales:	Angelos Papaspyropoulos, Orsalia Hazapis, Nefeli Lagopati, Aikaterini Polyzou, Anastasios D. Papanastasiou, Michalis Liontos, Vassilis G. Gorgoulis, Athanassios Kotsinas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	circRNA double-strand breaks (DSB) DNA damage response and repair (DDRR) tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/867a84eebed34b73a1fcc82995c6709f
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spelling	oai:doaj.org-article:867a84eebed34b73a1fcc82995c6709f2021-11-11T15:28:54ZThe Role of Circular RNAs in DNA Damage Response and Repair10.3390/cancers132153522072-6694https://doaj.org/article/867a84eebed34b73a1fcc82995c6709f2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5352https://doaj.org/toc/2072-6694Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs that are abundantly expressed in the cell. CircRNAs have the capacity to regulate gene expression by interacting with regulatory proteins and/or other classes of RNAs. While a vast number of circRNAs have been discovered, the majority still remains poorly characterized. Particularly, there is no detailed information on the identity and functional role of circRNAs that are transcribed from genes encoding components of the DNA damage response and repair (DDRR) network. In this article, we not only review the available published information on DDRR-related circRNAs, but also conduct a bioinformatic analysis on data obtained from public repositories to uncover deposited, yet uncharacterized circRNAs derived from components of the DDRR network. Finally, we interrogate for potential targets that are regulated by this class of molecules and look into potential functional implications.Angelos PapaspyropoulosOrsalia HazapisNefeli LagopatiAikaterini PolyzouAnastasios D. PapanastasiouMichalis LiontosVassilis G. GorgoulisAthanassios KotsinasMDPI AGarticlecircRNAdouble-strand breaks (DSB)DNA damage response and repair (DDRR)tumorigenesisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5352, p 5352 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA double-strand breaks (DSB) DNA damage response and repair (DDRR) tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	circRNA double-strand breaks (DSB) DNA damage response and repair (DDRR) tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Angelos Papaspyropoulos Orsalia Hazapis Nefeli Lagopati Aikaterini Polyzou Anastasios D. Papanastasiou Michalis Liontos Vassilis G. Gorgoulis Athanassios Kotsinas The Role of Circular RNAs in DNA Damage Response and Repair
description	Circular RNAs (circRNA) comprise a distinct class of non-coding RNAs that are abundantly expressed in the cell. CircRNAs have the capacity to regulate gene expression by interacting with regulatory proteins and/or other classes of RNAs. While a vast number of circRNAs have been discovered, the majority still remains poorly characterized. Particularly, there is no detailed information on the identity and functional role of circRNAs that are transcribed from genes encoding components of the DNA damage response and repair (DDRR) network. In this article, we not only review the available published information on DDRR-related circRNAs, but also conduct a bioinformatic analysis on data obtained from public repositories to uncover deposited, yet uncharacterized circRNAs derived from components of the DDRR network. Finally, we interrogate for potential targets that are regulated by this class of molecules and look into potential functional implications.
format	article
author	Angelos Papaspyropoulos Orsalia Hazapis Nefeli Lagopati Aikaterini Polyzou Anastasios D. Papanastasiou Michalis Liontos Vassilis G. Gorgoulis Athanassios Kotsinas
author_facet	Angelos Papaspyropoulos Orsalia Hazapis Nefeli Lagopati Aikaterini Polyzou Anastasios D. Papanastasiou Michalis Liontos Vassilis G. Gorgoulis Athanassios Kotsinas
author_sort	Angelos Papaspyropoulos
title	The Role of Circular RNAs in DNA Damage Response and Repair
title_short	The Role of Circular RNAs in DNA Damage Response and Repair
title_full	The Role of Circular RNAs in DNA Damage Response and Repair
title_fullStr	The Role of Circular RNAs in DNA Damage Response and Repair
title_full_unstemmed	The Role of Circular RNAs in DNA Damage Response and Repair
title_sort	role of circular rnas in dna damage response and repair
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/867a84eebed34b73a1fcc82995c6709f
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The Role of Circular RNAs in DNA Damage Response and Repair

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