TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice

TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice

Pachytene piRNAs are abundant piRNAs in mammalian adult testes but their biogenesis pathway is not fully understood. Here, the authors identify TDRD5 as a piRNA biogenesis factor in mice, showing that it binds piRNA precursors and promotes pachytene piRNA production from specific transcript regions.

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Autores principales: Deqiang Ding, Jiali Liu, Uros Midic, Yingjie Wu, Kunzhe Dong, Ashley Melnick, Keith E. Latham, Chen Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/867b39b3d88546afb8e004fc77485bc9
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spelling oai:doaj.org-article:867b39b3d88546afb8e004fc77485bc92021-12-02T16:50:09ZTDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice10.1038/s41467-017-02622-w2041-1723https://doaj.org/article/867b39b3d88546afb8e004fc77485bc92018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02622-whttps://doaj.org/toc/2041-1723Pachytene piRNAs are abundant piRNAs in mammalian adult testes but their biogenesis pathway is not fully understood. Here, the authors identify TDRD5 as a piRNA biogenesis factor in mice, showing that it binds piRNA precursors and promotes pachytene piRNA production from specific transcript regions.Deqiang DingJiali LiuUros MidicYingjie WuKunzhe DongAshley MelnickKeith E. LathamChen ChenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Deqiang Ding
Jiali Liu
Uros Midic
Yingjie Wu
Kunzhe Dong
Ashley Melnick
Keith E. Latham
Chen Chen
TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice
description Pachytene piRNAs are abundant piRNAs in mammalian adult testes but their biogenesis pathway is not fully understood. Here, the authors identify TDRD5 as a piRNA biogenesis factor in mice, showing that it binds piRNA precursors and promotes pachytene piRNA production from specific transcript regions.
format article
author Deqiang Ding
Jiali Liu
Uros Midic
Yingjie Wu
Kunzhe Dong
Ashley Melnick
Keith E. Latham
Chen Chen
author_facet Deqiang Ding
Jiali Liu
Uros Midic
Yingjie Wu
Kunzhe Dong
Ashley Melnick
Keith E. Latham
Chen Chen
author_sort Deqiang Ding
title TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice
title_short TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice
title_full TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice
title_fullStr TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice
title_full_unstemmed TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice
title_sort tdrd5 binds pirna precursors and selectively enhances pachytene pirna processing in mice
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/867b39b3d88546afb8e004fc77485bc9
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AT urosmidic tdrd5bindspirnaprecursorsandselectivelyenhancespachytenepirnaprocessinginmice
AT yingjiewu tdrd5bindspirnaprecursorsandselectivelyenhancespachytenepirnaprocessinginmice
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AT keithelatham tdrd5bindspirnaprecursorsandselectivelyenhancespachytenepirnaprocessinginmice
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