TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice

TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice

Pachytene piRNAs are abundant piRNAs in mammalian adult testes but their biogenesis pathway is not fully understood. Here, the authors identify TDRD5 as a piRNA biogenesis factor in mice, showing that it binds piRNA precursors and promotes pachytene piRNA production from specific transcript regions.

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Autores principales: Deqiang Ding, Jiali Liu, Uros Midic, Yingjie Wu, Kunzhe Dong, Ashley Melnick, Keith E. Latham, Chen Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/867b39b3d88546afb8e004fc77485bc9
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