ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations

Abstract ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation–based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built‐in PK/PD ordinary differential equations library of models to choose from alongsid...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Pavan Vaddady, Bhargava Kandala
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/8682781a848847c5a982559e09126690
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8682781a848847c5a982559e09126690
record_format	dspace
spelling	oai:doaj.org-article:8682781a848847c5a982559e091266902021-11-15T18:41:53ZModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations2163-830610.1002/psp4.12697https://doaj.org/article/8682781a848847c5a982559e091266902021-11-01T00:00:00Zhttps://doi.org/10.1002/psp4.12697https://doaj.org/toc/2163-8306Abstract ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation–based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built‐in PK/PD ordinary differential equations library of models to choose from alongside the ability to plug in a user‐defined model from a local or project directory. The user interface consists of several key inputs for performing the simulations as well as options to visualize the plots, perform simple noncompartmental analysis, and review inputs and model code. It also provides the ability to download the underlying model, plots, simulated data, or a comprehensive report consisting of all the key inputs and outputs of the simulations. The interface includes advanced features where users can overlay external data on a simulation, set a certain simulation scenario as a reference, or carry out sensitivity analysis–based simulations. This easy‐to‐use interface can serve as a valuable tool to project teams to evaluate potential scenarios facilitating collaborative decision making in the drug discovery and development paradigm.Pavan VaddadyBhargava KandalaWileyarticleTherapeutics. PharmacologyRM1-950ENCPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 11, Pp 1323-1331 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Therapeutics. Pharmacology RM1-950
spellingShingle	Therapeutics. Pharmacology RM1-950 Pavan Vaddady Bhargava Kandala ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
description	Abstract ModVizPop is an interactive and dynamic visualization tool developed for simulating differential equation–based population pharmacokinetic (PK) and pharmacodynamic (PD) models with variability. It has a built‐in PK/PD ordinary differential equations library of models to choose from alongside the ability to plug in a user‐defined model from a local or project directory. The user interface consists of several key inputs for performing the simulations as well as options to visualize the plots, perform simple noncompartmental analysis, and review inputs and model code. It also provides the ability to download the underlying model, plots, simulated data, or a comprehensive report consisting of all the key inputs and outputs of the simulations. The interface includes advanced features where users can overlay external data on a simulation, set a certain simulation scenario as a reference, or carry out sensitivity analysis–based simulations. This easy‐to‐use interface can serve as a valuable tool to project teams to evaluate potential scenarios facilitating collaborative decision making in the drug discovery and development paradigm.
format	article
author	Pavan Vaddady Bhargava Kandala
author_facet	Pavan Vaddady Bhargava Kandala
author_sort	Pavan Vaddady
title	ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_short	ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_full	ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_fullStr	ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_full_unstemmed	ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
title_sort	modvizpop: a shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/8682781a848847c5a982559e09126690
work_keys_str_mv	AT pavanvaddady modvizpopashinyinterfaceforempoweringteamstoperforminteractivepharmacokineticpharmacodynamicsimulations AT bhargavakandala modvizpopashinyinterfaceforempoweringteamstoperforminteractivepharmacokineticpharmacodynamicsimulations
_version_	1718426854498500608

ModVizPop: A shiny interface for empowering teams to perform interactive pharmacokinetic/pharmacodynamic simulations

Ejemplares similares