Molecular basis for heat desensitization of TRPV1 ion channels

The heat-sensitive ion channel TRPV1 is essential to temperature sensing in mammals and other animals. Here the authors find that the platypus form of TRPV1 does not desensitize, identify the mechanism underlying this property, and show that knock-in of this form of the receptor in mice leads to def...

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Autores principales:	Lei Luo, Yunfei Wang, Bowen Li, Lizhen Xu, Peter Muiruri Kamau, Jie Zheng, Fan Yang, Shilong Yang, Ren Lai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/868427a8865049d2ae95758095f5c20f
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spelling	oai:doaj.org-article:868427a8865049d2ae95758095f5c20f2021-12-02T15:36:00ZMolecular basis for heat desensitization of TRPV1 ion channels10.1038/s41467-019-09965-62041-1723https://doaj.org/article/868427a8865049d2ae95758095f5c20f2019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09965-6https://doaj.org/toc/2041-1723The heat-sensitive ion channel TRPV1 is essential to temperature sensing in mammals and other animals. Here the authors find that the platypus form of TRPV1 does not desensitize, identify the mechanism underlying this property, and show that knock-in of this form of the receptor in mice leads to deficits in heat sensitivity.Lei LuoYunfei WangBowen LiLizhen XuPeter Muiruri KamauJie ZhengFan YangShilong YangRen LaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lei Luo Yunfei Wang Bowen Li Lizhen Xu Peter Muiruri Kamau Jie Zheng Fan Yang Shilong Yang Ren Lai Molecular basis for heat desensitization of TRPV1 ion channels
description	The heat-sensitive ion channel TRPV1 is essential to temperature sensing in mammals and other animals. Here the authors find that the platypus form of TRPV1 does not desensitize, identify the mechanism underlying this property, and show that knock-in of this form of the receptor in mice leads to deficits in heat sensitivity.
format	article
author	Lei Luo Yunfei Wang Bowen Li Lizhen Xu Peter Muiruri Kamau Jie Zheng Fan Yang Shilong Yang Ren Lai
author_facet	Lei Luo Yunfei Wang Bowen Li Lizhen Xu Peter Muiruri Kamau Jie Zheng Fan Yang Shilong Yang Ren Lai
author_sort	Lei Luo
title	Molecular basis for heat desensitization of TRPV1 ion channels
title_short	Molecular basis for heat desensitization of TRPV1 ion channels
title_full	Molecular basis for heat desensitization of TRPV1 ion channels
title_fullStr	Molecular basis for heat desensitization of TRPV1 ion channels
title_full_unstemmed	Molecular basis for heat desensitization of TRPV1 ion channels
title_sort	molecular basis for heat desensitization of trpv1 ion channels
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/868427a8865049d2ae95758095f5c20f
work_keys_str_mv	AT leiluo molecularbasisforheatdesensitizationoftrpv1ionchannels AT yunfeiwang molecularbasisforheatdesensitizationoftrpv1ionchannels AT bowenli molecularbasisforheatdesensitizationoftrpv1ionchannels AT lizhenxu molecularbasisforheatdesensitizationoftrpv1ionchannels AT petermuirurikamau molecularbasisforheatdesensitizationoftrpv1ionchannels AT jiezheng molecularbasisforheatdesensitizationoftrpv1ionchannels AT fanyang molecularbasisforheatdesensitizationoftrpv1ionchannels AT shilongyang molecularbasisforheatdesensitizationoftrpv1ionchannels AT renlai molecularbasisforheatdesensitizationoftrpv1ionchannels
_version_	1718386364649570304

Molecular basis for heat desensitization of TRPV1 ion channels

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