Molecular basis for heat desensitization of TRPV1 ion channels
The heat-sensitive ion channel TRPV1 is essential to temperature sensing in mammals and other animals. Here the authors find that the platypus form of TRPV1 does not desensitize, identify the mechanism underlying this property, and show that knock-in of this form of the receptor in mice leads to def...
Guardado en:
Autores principales: | Lei Luo, Yunfei Wang, Bowen Li, Lizhen Xu, Peter Muiruri Kamau, Jie Zheng, Fan Yang, Shilong Yang, Ren Lai |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/868427a8865049d2ae95758095f5c20f |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Author Correction: Molecular basis for heat desensitization of TRPV1 ion channels
por: Lei Luo, et al.
Publicado: (2020) -
Conformational ensemble of the human TRPV3 ion channel
por: Lejla Zubcevic, et al.
Publicado: (2018) -
Molecular mechanisms underlying menthol binding and activation of TRPM8 ion channel
por: Lizhen Xu, et al.
Publicado: (2020) -
Structure of the full-length TRPV2 channel by cryo-EM
por: Kevin W. Huynh, et al.
Publicado: (2016) -
Swapping of transmembrane domains in the epithelial calcium channel TRPV6
por: Appu K. Singh, et al.
Publicado: (2017)