Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.

Intake of trans fatty acids (TFA), which are consumed by eating foods made from partially hydrogenated vegetable oils, is associated with a higher risk of cardiovascular disease. This relation can be explained by many factors including TFA's negative effect on endothelial function and reduced n...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Naomi G Iwata, Matilda Pham, Norma O Rizzo, Andrew M Cheng, Ezekiel Maloney, Francis Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/86868e0fe54b470195ad36fa839a2c6b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:86868e0fe54b470195ad36fa839a2c6b
record_format	dspace
spelling	oai:doaj.org-article:86868e0fe54b470195ad36fa839a2c6b2021-11-18T07:31:20ZTrans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.1932-620310.1371/journal.pone.0029600https://doaj.org/article/86868e0fe54b470195ad36fa839a2c6b2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22216328/?tool=EBIhttps://doaj.org/toc/1932-6203Intake of trans fatty acids (TFA), which are consumed by eating foods made from partially hydrogenated vegetable oils, is associated with a higher risk of cardiovascular disease. This relation can be explained by many factors including TFA's negative effect on endothelial function and reduced nitric oxide (NO) bioavailability. In this study we investigated the effects of three different TFA (2 common isomers of C18 found in partially hydrogenated vegetable oil and a C18 isomer found from ruminant-derived-dairy products and meat) on endothelial NF-κB activation and nitric oxide (NO) production. Human endothelial cells were treated with increasing concentrations of Elaidic (trans-C18:1 (9 trans)), Linoelaidic (trans-C18:2 (9 trans, 12 trans)), and Transvaccenic (trans-C18:1 (11 trans)) for 3 h. Both Elaidic and Linoelaidic acids were associated with increasing NF-κB activation as measured by IL-6 levels and phosphorylation of IκBα, and impairment of endothelial insulin signaling and NO production, whereas Transvaccenic acid was not associated with these responses. We also measured superoxide production, which has been hypothesized to be necessary in fatty acid-dependent activation of NF-κB. Both Elaidic acid and Linoelaidic acid are associated with increased superoxide production, whereas Transvaccenic acid (which did not induce inflammatory responses) did not increase superoxide production. We observed differential activation of endothelial superoxide production, NF-κB activation, and reduction in NO production by different C18 isomers suggesting that the location and number of trans double bonds effect endothelial NF-κB activation.Naomi G IwataMatilda PhamNorma O RizzoAndrew M ChengEzekiel MaloneyFrancis KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e29600 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naomi G Iwata Matilda Pham Norma O Rizzo Andrew M Cheng Ezekiel Maloney Francis Kim Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.
description	Intake of trans fatty acids (TFA), which are consumed by eating foods made from partially hydrogenated vegetable oils, is associated with a higher risk of cardiovascular disease. This relation can be explained by many factors including TFA's negative effect on endothelial function and reduced nitric oxide (NO) bioavailability. In this study we investigated the effects of three different TFA (2 common isomers of C18 found in partially hydrogenated vegetable oil and a C18 isomer found from ruminant-derived-dairy products and meat) on endothelial NF-κB activation and nitric oxide (NO) production. Human endothelial cells were treated with increasing concentrations of Elaidic (trans-C18:1 (9 trans)), Linoelaidic (trans-C18:2 (9 trans, 12 trans)), and Transvaccenic (trans-C18:1 (11 trans)) for 3 h. Both Elaidic and Linoelaidic acids were associated with increasing NF-κB activation as measured by IL-6 levels and phosphorylation of IκBα, and impairment of endothelial insulin signaling and NO production, whereas Transvaccenic acid was not associated with these responses. We also measured superoxide production, which has been hypothesized to be necessary in fatty acid-dependent activation of NF-κB. Both Elaidic acid and Linoelaidic acid are associated with increased superoxide production, whereas Transvaccenic acid (which did not induce inflammatory responses) did not increase superoxide production. We observed differential activation of endothelial superoxide production, NF-κB activation, and reduction in NO production by different C18 isomers suggesting that the location and number of trans double bonds effect endothelial NF-κB activation.
format	article
author	Naomi G Iwata Matilda Pham Norma O Rizzo Andrew M Cheng Ezekiel Maloney Francis Kim
author_facet	Naomi G Iwata Matilda Pham Norma O Rizzo Andrew M Cheng Ezekiel Maloney Francis Kim
author_sort	Naomi G Iwata
title	Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.
title_short	Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.
title_full	Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.
title_fullStr	Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.
title_full_unstemmed	Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.
title_sort	trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/86868e0fe54b470195ad36fa839a2c6b
work_keys_str_mv	AT naomigiwata transfattyacidsinducevascularinflammationandreducevascularnitricoxideproductioninendothelialcells AT matildapham transfattyacidsinducevascularinflammationandreducevascularnitricoxideproductioninendothelialcells AT normaorizzo transfattyacidsinducevascularinflammationandreducevascularnitricoxideproductioninendothelialcells AT andrewmcheng transfattyacidsinducevascularinflammationandreducevascularnitricoxideproductioninendothelialcells AT ezekielmaloney transfattyacidsinducevascularinflammationandreducevascularnitricoxideproductioninendothelialcells AT franciskim transfattyacidsinducevascularinflammationandreducevascularnitricoxideproductioninendothelialcells
_version_	1718423356180529152

Trans fatty acids induce vascular inflammation and reduce vascular nitric oxide production in endothelial cells.

Ejemplares similares