CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression

The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma are still unclear. Here we collected lymphoma t...

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Autores principales:	Chen Yan, Li Meng, Cao Jian, Cai Guohong, Li Xiantao, Liu Yuejiao, Chen Wen
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	lymphoma ctla-4 regulatory t cell tumor stem cell Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/86871cff5db446d0a4029a83abc1aef7
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spelling	oai:doaj.org-article:86871cff5db446d0a4029a83abc1aef72021-12-05T14:10:41ZCTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression2391-541210.1515/biol-2021-0094https://doaj.org/article/86871cff5db446d0a4029a83abc1aef72021-09-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0094https://doaj.org/toc/2391-5412The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma are still unclear. Here we collected lymphoma tissue and peripheral blood from patients with diffuse large B-cell lymphoma (DLBCL). Results showed that CTLA-4 expression and CD44+ cell in the high-risk group were significantly higher than that in the low-risk group. Correlation analysis showed that CTLA-4 expression positively correlated with CD44+ cell in lymphoma tissue and regulatory T (Treg) cells in lymphocytes. In vitro experiment showed that CTLA-4 increased the ratio of lymphoma stem cells, and proliferation and invasion of lymphoma cells through TGF-β pathway. Moreover, CTLA-4 enhanced the proliferation of Treg cells induced by lymphoma cells. Animal experiments showed that CTLA-4 can promote transplanted lymphoma growth. Immunohistochemistry results showed that both Ki-67 and CD44+ cells increased significantly in the CTLA-4 group. TGF-β neutralization can significantly block these effects of CTLA-4. In conclusion, CTLA-4 promoted DLBCL progression through lymphoma stem cell enrichment and immunosuppression.Chen YanLi MengCao JianCai GuohongLi XiantaoLiu YuejiaoChen WenDe Gruyterarticlelymphomactla-4regulatory t celltumor stem cellBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 909-919 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lymphoma ctla-4 regulatory t cell tumor stem cell Biology (General) QH301-705.5
spellingShingle	lymphoma ctla-4 regulatory t cell tumor stem cell Biology (General) QH301-705.5 Chen Yan Li Meng Cao Jian Cai Guohong Li Xiantao Liu Yuejiao Chen Wen CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
description	The recurrence rate of lymphoma is very high, and tumor stem cells may be an important mechanism. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can inhibit antitumor immunity and promote cancer progression, but its role and mechanism in lymphoma are still unclear. Here we collected lymphoma tissue and peripheral blood from patients with diffuse large B-cell lymphoma (DLBCL). Results showed that CTLA-4 expression and CD44+ cell in the high-risk group were significantly higher than that in the low-risk group. Correlation analysis showed that CTLA-4 expression positively correlated with CD44+ cell in lymphoma tissue and regulatory T (Treg) cells in lymphocytes. In vitro experiment showed that CTLA-4 increased the ratio of lymphoma stem cells, and proliferation and invasion of lymphoma cells through TGF-β pathway. Moreover, CTLA-4 enhanced the proliferation of Treg cells induced by lymphoma cells. Animal experiments showed that CTLA-4 can promote transplanted lymphoma growth. Immunohistochemistry results showed that both Ki-67 and CD44+ cells increased significantly in the CTLA-4 group. TGF-β neutralization can significantly block these effects of CTLA-4. In conclusion, CTLA-4 promoted DLBCL progression through lymphoma stem cell enrichment and immunosuppression.
format	article
author	Chen Yan Li Meng Cao Jian Cai Guohong Li Xiantao Liu Yuejiao Chen Wen
author_facet	Chen Yan Li Meng Cao Jian Cai Guohong Li Xiantao Liu Yuejiao Chen Wen
author_sort	Chen Yan
title	CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
title_short	CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
title_full	CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
title_fullStr	CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
title_full_unstemmed	CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
title_sort	ctla-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/86871cff5db446d0a4029a83abc1aef7
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CTLA-4 promotes lymphoma progression through tumor stem cell enrichment and immunosuppression

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