The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries

Abstract Wall shear stress (WSS), the frictional force of the blood on the vessel wall, plays a crucial role in atherosclerotic plaque development. Low WSS has been associated with plaque growth, however previous research used different approaches to define low WSS to investigate its effect on plaqu...

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Autores principales:	Eline M. J. Hartman, Giuseppe De Nisco, Frank J. H. Gijsen, Suze-Anne Korteland, Anton F. W. van der Steen, Joost Daemen, Jolanda J. Wentzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/868ad3401d0641db9538bbafb6bb82d8
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spelling	oai:doaj.org-article:868ad3401d0641db9538bbafb6bb82d82021-11-14T12:18:12ZThe definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries10.1038/s41598-021-01232-32045-2322https://doaj.org/article/868ad3401d0641db9538bbafb6bb82d82021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01232-3https://doaj.org/toc/2045-2322Abstract Wall shear stress (WSS), the frictional force of the blood on the vessel wall, plays a crucial role in atherosclerotic plaque development. Low WSS has been associated with plaque growth, however previous research used different approaches to define low WSS to investigate its effect on plaque progression. In this study, we used four methodologies to allocate low, mid and high WSS in one dataset of human coronary arteries and investigated the predictive power of low WSS for plaque progression. Coronary reconstructions were based on multimodality imaging, using intravascular ultrasound and CT-imaging. Vessel-specific flow was measured using Doppler wire and computational fluid dynamics was performed to calculate WSS. The absolute WSS range varied greatly between the coronary arteries. On the population level, the established pattern of most plaque progression at low WSS was apparent in all methodologies defining the WSS categories. However, for the individual patient, when using measured flow to determine WSS, the absolute WSS values range so widely, that the use of absolute thresholds to determine low WSS was not appropriate to identify regions at high risk for plaque progression.Eline M. J. HartmanGiuseppe De NiscoFrank J. H. GijsenSuze-Anne KortelandAnton F. W. van der SteenJoost DaemenJolanda J. WentzelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eline M. J. Hartman Giuseppe De Nisco Frank J. H. Gijsen Suze-Anne Korteland Anton F. W. van der Steen Joost Daemen Jolanda J. Wentzel The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries
description	Abstract Wall shear stress (WSS), the frictional force of the blood on the vessel wall, plays a crucial role in atherosclerotic plaque development. Low WSS has been associated with plaque growth, however previous research used different approaches to define low WSS to investigate its effect on plaque progression. In this study, we used four methodologies to allocate low, mid and high WSS in one dataset of human coronary arteries and investigated the predictive power of low WSS for plaque progression. Coronary reconstructions were based on multimodality imaging, using intravascular ultrasound and CT-imaging. Vessel-specific flow was measured using Doppler wire and computational fluid dynamics was performed to calculate WSS. The absolute WSS range varied greatly between the coronary arteries. On the population level, the established pattern of most plaque progression at low WSS was apparent in all methodologies defining the WSS categories. However, for the individual patient, when using measured flow to determine WSS, the absolute WSS values range so widely, that the use of absolute thresholds to determine low WSS was not appropriate to identify regions at high risk for plaque progression.
format	article
author	Eline M. J. Hartman Giuseppe De Nisco Frank J. H. Gijsen Suze-Anne Korteland Anton F. W. van der Steen Joost Daemen Jolanda J. Wentzel
author_facet	Eline M. J. Hartman Giuseppe De Nisco Frank J. H. Gijsen Suze-Anne Korteland Anton F. W. van der Steen Joost Daemen Jolanda J. Wentzel
author_sort	Eline M. J. Hartman
title	The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries
title_short	The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries
title_full	The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries
title_fullStr	The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries
title_full_unstemmed	The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries
title_sort	definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/868ad3401d0641db9538bbafb6bb82d8
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The definition of low wall shear stress and its effect on plaque progression estimation in human coronary arteries

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