Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.

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Autores principales:	Hong-pyo Lee, Ryan Stowers, Ovijit Chaudhuri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86911035bc2748da8dab6100140e824a
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spelling	oai:doaj.org-article:86911035bc2748da8dab6100140e824a2021-12-02T16:57:34ZVolume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments10.1038/s41467-019-08465-x2041-1723https://doaj.org/article/86911035bc2748da8dab6100140e824a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08465-xhttps://doaj.org/toc/2041-1723For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.Hong-pyo LeeRyan StowersOvijit ChaudhuriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hong-pyo Lee Ryan Stowers Ovijit Chaudhuri Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
description	For mesenchymal stem cells (MSCs), matrix remodeling is associated with enhanced osteogenic differentiation. Here authors find that MSCs in viscoelastic hydrogels exhibit volume expansion during cell spreading, and greater volume expansion is associated with enhanced osteogenesis.
format	article
author	Hong-pyo Lee Ryan Stowers Ovijit Chaudhuri
author_facet	Hong-pyo Lee Ryan Stowers Ovijit Chaudhuri
author_sort	Hong-pyo Lee
title	Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_short	Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_full	Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_fullStr	Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_full_unstemmed	Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments
title_sort	volume expansion and trpv4 activation regulate stem cell fate in three-dimensional microenvironments
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/86911035bc2748da8dab6100140e824a
work_keys_str_mv	AT hongpyolee volumeexpansionandtrpv4activationregulatestemcellfateinthreedimensionalmicroenvironments AT ryanstowers volumeexpansionandtrpv4activationregulatestemcellfateinthreedimensionalmicroenvironments AT ovijitchaudhuri volumeexpansionandtrpv4activationregulatestemcellfateinthreedimensionalmicroenvironments
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Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

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