The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma

The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma

Abstract The long noncoding RNASBF2-AS1 can promote the occurrence and development of many kinds of tumours, but its role in oesophageal squamous cell carcinoma (ESCC) is unknown. We found that SBF2-AS1 was up-regulated in ESCC, and its expression was positively correlated with tumor size (P = 0.000...

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Autores principales: Wenjuan Zha, Xiaomin Li, Xiaowei Tie, Yao Xing, Hao Li, Fei Gao, Ting Ye, Wangqi Du, Rui Chen, Yangchen Liu
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/869180d850dc4d1082a224d7a29275df
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spelling oai:doaj.org-article:869180d850dc4d1082a224d7a29275df2021-12-02T15:23:07ZThe molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma10.1038/s41598-020-80817-w2045-2322https://doaj.org/article/869180d850dc4d1082a224d7a29275df2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80817-whttps://doaj.org/toc/2045-2322Abstract The long noncoding RNASBF2-AS1 can promote the occurrence and development of many kinds of tumours, but its role in oesophageal squamous cell carcinoma (ESCC) is unknown. We found that SBF2-AS1 was up-regulated in ESCC, and its expression was positively correlated with tumor size (P = 0.0001), but was not related to gender, age, TNM stage, histological grade, and lymphnode metastasis (P > 0.05). It was further found that the higher the expression of SBF2-AS1, the lower the survival rate. COX multivariate analysis showed that the expression of SBF2-AS1 was an independent prognostic factor. Functional experiments show that inhibition of SBF2-AS1 can inhibit the proliferation of ESCC through in vivo and in vitro, and overexpression of SBF2-AS1 can promote the proliferation of ESCC and inhibit its apoptosis. In mechanism, SBF2-AS1/miR-338-3P, miR-362-3P/E2F1 axis are involved in the regulation of ESCC growth. In general, SBF2-AS1 may be used as ceRNA to combine with miR-338-3P and miR-362-3P to up-regulate the expression ofE2F1, and ultimately play a role in promoting cancer. It may be used as a therapeutic target and a biomarker for prognosis.Wenjuan ZhaXiaomin LiXiaowei TieYao XingHao LiFei GaoTing YeWangqi DuRui ChenYangchen LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Wenjuan Zha
Xiaomin Li
Xiaowei Tie
Yao Xing
Hao Li
Fei Gao
Ting Ye
Wangqi Du
Rui Chen
Yangchen Liu
The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma
description Abstract The long noncoding RNASBF2-AS1 can promote the occurrence and development of many kinds of tumours, but its role in oesophageal squamous cell carcinoma (ESCC) is unknown. We found that SBF2-AS1 was up-regulated in ESCC, and its expression was positively correlated with tumor size (P = 0.0001), but was not related to gender, age, TNM stage, histological grade, and lymphnode metastasis (P > 0.05). It was further found that the higher the expression of SBF2-AS1, the lower the survival rate. COX multivariate analysis showed that the expression of SBF2-AS1 was an independent prognostic factor. Functional experiments show that inhibition of SBF2-AS1 can inhibit the proliferation of ESCC through in vivo and in vitro, and overexpression of SBF2-AS1 can promote the proliferation of ESCC and inhibit its apoptosis. In mechanism, SBF2-AS1/miR-338-3P, miR-362-3P/E2F1 axis are involved in the regulation of ESCC growth. In general, SBF2-AS1 may be used as ceRNA to combine with miR-338-3P and miR-362-3P to up-regulate the expression ofE2F1, and ultimately play a role in promoting cancer. It may be used as a therapeutic target and a biomarker for prognosis.
format article
author Wenjuan Zha
Xiaomin Li
Xiaowei Tie
Yao Xing
Hao Li
Fei Gao
Ting Ye
Wangqi Du
Rui Chen
Yangchen Liu
author_facet Wenjuan Zha
Xiaomin Li
Xiaowei Tie
Yao Xing
Hao Li
Fei Gao
Ting Ye
Wangqi Du
Rui Chen
Yangchen Liu
author_sort Wenjuan Zha
title The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma
title_short The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma
title_full The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma
title_fullStr The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma
title_full_unstemmed The molecular mechanisms of the long noncoding RNA SBF2-AS1 in regulating the proliferation of oesophageal squamous cell carcinoma
title_sort molecular mechanisms of the long noncoding rna sbf2-as1 in regulating the proliferation of oesophageal squamous cell carcinoma
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/869180d850dc4d1082a224d7a29275df
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