Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia

Abstract Acupuncture has been used to treat a variety of illness and involves the insertion and manipulation of needles into specific points on the body (termed “acupoints”). It has been suggested that acupoints are not merely discrete, static points, but can be dynamically changed according to the...

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Autores principales:	Yu Fan, Yeonhee Ryu, Rongjie Zhao, Kyle B. Bills, Scott C. Steffensen, Chae Ha Yang, Hee Young Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8693fc4062d642ee9d9527a47a4aed2e
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spelling	oai:doaj.org-article:8693fc4062d642ee9d9527a47a4aed2e2021-12-02T17:45:21ZEnhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia10.1038/s41598-020-67242-92045-2322https://doaj.org/article/8693fc4062d642ee9d9527a47a4aed2e2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-67242-9https://doaj.org/toc/2045-2322Abstract Acupuncture has been used to treat a variety of illness and involves the insertion and manipulation of needles into specific points on the body (termed “acupoints”). It has been suggested that acupoints are not merely discrete, static points, but can be dynamically changed according to the pathological state of internal organs. We investigated in a rat model of mustard oil (MO)-induced visceral hyperalgesia whether the number and size of acupoints were modified according to the severity of the colonic pain, and whether the changes were associated with enhanced activity of the spinal dorsal horn. In MO-treated rats, acupoints showing neurogenic inflammation (termed “neurogenic spots” or Neuro-Sps) were found both bilaterally and unilaterally on the leg. The number and size of these acupoints increased along with increasing doses of MO. Electroacupuncture of the acupoints generated analgesic effects on MO-induced visceral hypersensitivity. The MO-treated rats showed an increase in c-Fos expression in spinal dorsal horn neurons and displayed increased evoked activity and a prolonged after-discharge in spinal wide dynamic response (WDR) neurons in response to colorectal distension. Increased number and size of neurogenic inflammatory acupoints following MO treatment were reduced by inhibiting AMPA and NMDA receptors in the spinal cord. Our findings suggest that acupoints demonstrate increased number and size along with severity of visceral pain, which may be associated with enhanced neuronal responses in spinal dorsal horn neurons.Yu FanYeonhee RyuRongjie ZhaoKyle B. BillsScott C. SteffensenChae Ha YangHee Young KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Fan Yeonhee Ryu Rongjie Zhao Kyle B. Bills Scott C. Steffensen Chae Ha Yang Hee Young Kim Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
description	Abstract Acupuncture has been used to treat a variety of illness and involves the insertion and manipulation of needles into specific points on the body (termed “acupoints”). It has been suggested that acupoints are not merely discrete, static points, but can be dynamically changed according to the pathological state of internal organs. We investigated in a rat model of mustard oil (MO)-induced visceral hyperalgesia whether the number and size of acupoints were modified according to the severity of the colonic pain, and whether the changes were associated with enhanced activity of the spinal dorsal horn. In MO-treated rats, acupoints showing neurogenic inflammation (termed “neurogenic spots” or Neuro-Sps) were found both bilaterally and unilaterally on the leg. The number and size of these acupoints increased along with increasing doses of MO. Electroacupuncture of the acupoints generated analgesic effects on MO-induced visceral hypersensitivity. The MO-treated rats showed an increase in c-Fos expression in spinal dorsal horn neurons and displayed increased evoked activity and a prolonged after-discharge in spinal wide dynamic response (WDR) neurons in response to colorectal distension. Increased number and size of neurogenic inflammatory acupoints following MO treatment were reduced by inhibiting AMPA and NMDA receptors in the spinal cord. Our findings suggest that acupoints demonstrate increased number and size along with severity of visceral pain, which may be associated with enhanced neuronal responses in spinal dorsal horn neurons.
format	article
author	Yu Fan Yeonhee Ryu Rongjie Zhao Kyle B. Bills Scott C. Steffensen Chae Ha Yang Hee Young Kim
author_facet	Yu Fan Yeonhee Ryu Rongjie Zhao Kyle B. Bills Scott C. Steffensen Chae Ha Yang Hee Young Kim
author_sort	Yu Fan
title	Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
title_short	Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
title_full	Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
title_fullStr	Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
title_full_unstemmed	Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
title_sort	enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8693fc4062d642ee9d9527a47a4aed2e
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Enhanced spinal neuronal responses as a mechanism for increased number and size of active acupoints in visceral hyperalgesia

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