PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sivakumar Vadivel Gnanasundram, Slovénie Pyndiah, Chrysoula Daskalogianni, Kate Armfield, Karin Nylander, Joanna B. Wilson, Robin Fåhraeus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/869477af35b34d6ba3566d32e1799f29
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:869477af35b34d6ba3566d32e1799f29
record_format	dspace
spelling	oai:doaj.org-article:869477af35b34d6ba3566d32e1799f292021-12-02T14:43:00ZPI3Kδ activates E2F1 synthesis in response to mRNA translation stress10.1038/s41467-017-02282-w2041-1723https://doaj.org/article/869477af35b34d6ba3566d32e1799f292017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02282-whttps://doaj.org/toc/2041-1723The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation.Sivakumar Vadivel GnanasundramSlovénie PyndiahChrysoula DaskalogianniKate ArmfieldKarin NylanderJoanna B. WilsonRobin FåhraeusNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sivakumar Vadivel Gnanasundram Slovénie Pyndiah Chrysoula Daskalogianni Kate Armfield Karin Nylander Joanna B. Wilson Robin Fåhraeus PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
description	The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation.
format	article
author	Sivakumar Vadivel Gnanasundram Slovénie Pyndiah Chrysoula Daskalogianni Kate Armfield Karin Nylander Joanna B. Wilson Robin Fåhraeus
author_facet	Sivakumar Vadivel Gnanasundram Slovénie Pyndiah Chrysoula Daskalogianni Kate Armfield Karin Nylander Joanna B. Wilson Robin Fåhraeus
author_sort	Sivakumar Vadivel Gnanasundram
title	PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
title_short	PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
title_full	PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
title_fullStr	PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
title_full_unstemmed	PI3Kδ activates E2F1 synthesis in response to mRNA translation stress
title_sort	pi3kδ activates e2f1 synthesis in response to mrna translation stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/869477af35b34d6ba3566d32e1799f29
work_keys_str_mv	AT sivakumarvadivelgnanasundram pi3kdactivatese2f1synthesisinresponsetomrnatranslationstress AT sloveniepyndiah pi3kdactivatese2f1synthesisinresponsetomrnatranslationstress AT chrysouladaskalogianni pi3kdactivatese2f1synthesisinresponsetomrnatranslationstress AT katearmfield pi3kdactivatese2f1synthesisinresponsetomrnatranslationstress AT karinnylander pi3kdactivatese2f1synthesisinresponsetomrnatranslationstress AT joannabwilson pi3kdactivatese2f1synthesisinresponsetomrnatranslationstress AT robinfahraeus pi3kdactivatese2f1synthesisinresponsetomrnatranslationstress
_version_	1718389580562956288

PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

Ejemplares similares