Khat and neurobehavioral functions: A systematic review.

<h4>Background</h4>Khat is a plant that is used for its amphetamine-like stimulant properties. However, although khat is very popular in Eastern Africa, Arabian Peninsula, and the Middle East, there is still a lack of studies researching the possible neurobehavioral impairment derived fr...

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Autores principales:	Ayan Ahmed, Manuel J Ruiz, Kathrin Cohen Kadosh, Robert Patton, Davinia M Resurrección
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8697120a52f94feabd63179a5f17848d
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spelling	oai:doaj.org-article:8697120a52f94feabd63179a5f17848d2021-12-02T20:10:49ZKhat and neurobehavioral functions: A systematic review.1932-620310.1371/journal.pone.0252900https://doaj.org/article/8697120a52f94feabd63179a5f17848d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252900https://doaj.org/toc/1932-6203<h4>Background</h4>Khat is a plant that is used for its amphetamine-like stimulant properties. However, although khat is very popular in Eastern Africa, Arabian Peninsula, and the Middle East, there is still a lack of studies researching the possible neurobehavioral impairment derived from khat use.<h4>Methods</h4>A systematic review was conducted to identify studies that assessed the effects of khat use on neurobehavioral functions. MedLine, Scopus, Cochrane, Web of Science and Open Grey literature were searched for relevant publications from inception to December 2020. Search terms included (a) khat and (b) several cognitive domains. References from relevant publications and grey literature were also reviewed to identify additional citations for inclusion.<h4>Results</h4>A total of 142 articles were reviewed, 14 of which met the inclusion criteria (nine human and five rodent studies). Available human studies suggest that long term khat use is associated with significant deficits in several cognitive domains, including learning, motor speed/coordination, set-shifting/response inhibition functions, cognitive flexibility, short term/working memory, and conflict resolution. In addition, rodent studies indicated daily administration of khat extract resulted in dose-related impairments in behavior such as motor hyperactivity and decreased cognition, mainly learning and memory.<h4>Conclusions</h4>The findings presented in this review indicates that long-term khat use may be contributing to an impairment of neurobehavioral functions. However, gaps in literature were detected that future studies could potentially address to better understand the health consequences of khat use.Ayan AhmedManuel J RuizKathrin Cohen KadoshRobert PattonDavinia M ResurrecciónPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252900 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayan Ahmed Manuel J Ruiz Kathrin Cohen Kadosh Robert Patton Davinia M Resurrección Khat and neurobehavioral functions: A systematic review.
description	<h4>Background</h4>Khat is a plant that is used for its amphetamine-like stimulant properties. However, although khat is very popular in Eastern Africa, Arabian Peninsula, and the Middle East, there is still a lack of studies researching the possible neurobehavioral impairment derived from khat use.<h4>Methods</h4>A systematic review was conducted to identify studies that assessed the effects of khat use on neurobehavioral functions. MedLine, Scopus, Cochrane, Web of Science and Open Grey literature were searched for relevant publications from inception to December 2020. Search terms included (a) khat and (b) several cognitive domains. References from relevant publications and grey literature were also reviewed to identify additional citations for inclusion.<h4>Results</h4>A total of 142 articles were reviewed, 14 of which met the inclusion criteria (nine human and five rodent studies). Available human studies suggest that long term khat use is associated with significant deficits in several cognitive domains, including learning, motor speed/coordination, set-shifting/response inhibition functions, cognitive flexibility, short term/working memory, and conflict resolution. In addition, rodent studies indicated daily administration of khat extract resulted in dose-related impairments in behavior such as motor hyperactivity and decreased cognition, mainly learning and memory.<h4>Conclusions</h4>The findings presented in this review indicates that long-term khat use may be contributing to an impairment of neurobehavioral functions. However, gaps in literature were detected that future studies could potentially address to better understand the health consequences of khat use.
format	article
author	Ayan Ahmed Manuel J Ruiz Kathrin Cohen Kadosh Robert Patton Davinia M Resurrección
author_facet	Ayan Ahmed Manuel J Ruiz Kathrin Cohen Kadosh Robert Patton Davinia M Resurrección
author_sort	Ayan Ahmed
title	Khat and neurobehavioral functions: A systematic review.
title_short	Khat and neurobehavioral functions: A systematic review.
title_full	Khat and neurobehavioral functions: A systematic review.
title_fullStr	Khat and neurobehavioral functions: A systematic review.
title_full_unstemmed	Khat and neurobehavioral functions: A systematic review.
title_sort	khat and neurobehavioral functions: a systematic review.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8697120a52f94feabd63179a5f17848d
work_keys_str_mv	AT ayanahmed khatandneurobehavioralfunctionsasystematicreview AT manueljruiz khatandneurobehavioralfunctionsasystematicreview AT kathrincohenkadosh khatandneurobehavioralfunctionsasystematicreview AT robertpatton khatandneurobehavioralfunctionsasystematicreview AT daviniamresurreccion khatandneurobehavioralfunctionsasystematicreview
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Khat and neurobehavioral functions: A systematic review.

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