Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients

The corticospinal tract (CST) and corticocerebellar tract (CCT) are both involved in the upper extremity (UE) function after stroke. Understanding the relationship between the tracts and their functions can contribute to developing patient-specific rehabilitative strategies. Seventy ischemic stroke...

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Autores principales:	Jungsoo Lee, Won Hyuk Chang, Yun-Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stroke motor recovery corticospinal tract corticocerebellar tract Medicine R
Acceso en línea:	https://doaj.org/article/8698bdad420047c9a0bf95d869760464
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spelling	oai:doaj.org-article:8698bdad420047c9a0bf95d8697604642021-11-25T18:07:39ZRelationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients10.3390/jpm111111622075-4426https://doaj.org/article/8698bdad420047c9a0bf95d8697604642021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1162https://doaj.org/toc/2075-4426The corticospinal tract (CST) and corticocerebellar tract (CCT) are both involved in the upper extremity (UE) function after stroke. Understanding the relationship between the tracts and their functions can contribute to developing patient-specific rehabilitative strategies. Seventy ischemic stroke patients who underwent diffusion tensor imaging (DTI) two weeks after the stroke onset and motor function assessments two weeks and three months after the stroke onset were included in this study. To obtain the CST and CCT integrity, the functional anisotropy (FA) values of both tracts were extracted from the DTI data. Linear regression was used to identify the relationship and predictive accuracy. The CST FA data had predictive values, but CCT FA did not. There were interaction effects between the CST and CCT FA values (<i>p</i> = 0.011). The CCT was significantly associated with high CST FA but not low CST FA. When the CST or CCT FA were applied to patients depending on the CST status, the stratified model showed higher predictive accuracy (<i>R</i><sup>2</sup> = 0.380) than that of the CST-only model (<i>R</i><sup>2</sup> = 0.320). In this study, the conditional role of CCT depending on CST status was identified in terms of UE recovery in stroke patients. This result could provide useful information about individualized rehabilitative strategies in stroke patients.Jungsoo LeeWon Hyuk ChangYun-Hee KimMDPI AGarticlestrokemotor recoverycorticospinal tractcorticocerebellar tractMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1162, p 1162 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke motor recovery corticospinal tract corticocerebellar tract Medicine R
spellingShingle	stroke motor recovery corticospinal tract corticocerebellar tract Medicine R Jungsoo Lee Won Hyuk Chang Yun-Hee Kim Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients
description	The corticospinal tract (CST) and corticocerebellar tract (CCT) are both involved in the upper extremity (UE) function after stroke. Understanding the relationship between the tracts and their functions can contribute to developing patient-specific rehabilitative strategies. Seventy ischemic stroke patients who underwent diffusion tensor imaging (DTI) two weeks after the stroke onset and motor function assessments two weeks and three months after the stroke onset were included in this study. To obtain the CST and CCT integrity, the functional anisotropy (FA) values of both tracts were extracted from the DTI data. Linear regression was used to identify the relationship and predictive accuracy. The CST FA data had predictive values, but CCT FA did not. There were interaction effects between the CST and CCT FA values (<i>p</i> = 0.011). The CCT was significantly associated with high CST FA but not low CST FA. When the CST or CCT FA were applied to patients depending on the CST status, the stratified model showed higher predictive accuracy (<i>R</i><sup>2</sup> = 0.380) than that of the CST-only model (<i>R</i><sup>2</sup> = 0.320). In this study, the conditional role of CCT depending on CST status was identified in terms of UE recovery in stroke patients. This result could provide useful information about individualized rehabilitative strategies in stroke patients.
format	article
author	Jungsoo Lee Won Hyuk Chang Yun-Hee Kim
author_facet	Jungsoo Lee Won Hyuk Chang Yun-Hee Kim
author_sort	Jungsoo Lee
title	Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients
title_short	Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients
title_full	Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients
title_fullStr	Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients
title_full_unstemmed	Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients
title_sort	relationship between the corticospinal and corticocerebellar tracts and their role in upper extremity motor recovery in stroke patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8698bdad420047c9a0bf95d869760464
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Relationship between the Corticospinal and Corticocerebellar Tracts and Their Role in Upper Extremity Motor Recovery in Stroke Patients

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