Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.
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Nature Portfolio
2018
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oai:doaj.org-article:86a0b1965c3547f0820ef0dd3daf13b62021-12-02T14:39:47ZHaploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice10.1038/s41467-018-06584-52041-1723https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06584-5https://doaj.org/toc/2041-1723Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.Virginie CourchetAmanda J. RobertsGéraldine Meyer-DilhetPeggy Del CarmineTommy L. LewisFranck PolleuxJulien CourchetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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Science Q Virginie Courchet Amanda J. Roberts Géraldine Meyer-Dilhet Peggy Del Carmine Tommy L. Lewis Franck Polleux Julien Courchet Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice |
description |
Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders. |
format |
article |
author |
Virginie Courchet Amanda J. Roberts Géraldine Meyer-Dilhet Peggy Del Carmine Tommy L. Lewis Franck Polleux Julien Courchet |
author_facet |
Virginie Courchet Amanda J. Roberts Géraldine Meyer-Dilhet Peggy Del Carmine Tommy L. Lewis Franck Polleux Julien Courchet |
author_sort |
Virginie Courchet |
title |
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice |
title_short |
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice |
title_full |
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice |
title_fullStr |
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice |
title_full_unstemmed |
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice |
title_sort |
haploinsufficiency of autism spectrum disorder candidate gene nuak1 impairs cortical development and behavior in mice |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6 |
work_keys_str_mv |
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