Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice

Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.

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Autores principales: Virginie Courchet, Amanda J. Roberts, Géraldine Meyer-Dilhet, Peggy Del Carmine, Tommy L. Lewis, Franck Polleux, Julien Courchet
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6
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spelling oai:doaj.org-article:86a0b1965c3547f0820ef0dd3daf13b62021-12-02T14:39:47ZHaploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice10.1038/s41467-018-06584-52041-1723https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06584-5https://doaj.org/toc/2041-1723Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.Virginie CourchetAmanda J. RobertsGéraldine Meyer-DilhetPeggy Del CarmineTommy L. LewisFranck PolleuxJulien CourchetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Virginie Courchet
Amanda J. Roberts
Géraldine Meyer-Dilhet
Peggy Del Carmine
Tommy L. Lewis
Franck Polleux
Julien Courchet
Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
description Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.
format article
author Virginie Courchet
Amanda J. Roberts
Géraldine Meyer-Dilhet
Peggy Del Carmine
Tommy L. Lewis
Franck Polleux
Julien Courchet
author_facet Virginie Courchet
Amanda J. Roberts
Géraldine Meyer-Dilhet
Peggy Del Carmine
Tommy L. Lewis
Franck Polleux
Julien Courchet
author_sort Virginie Courchet
title Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_short Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_full Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_fullStr Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_full_unstemmed Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_sort haploinsufficiency of autism spectrum disorder candidate gene nuak1 impairs cortical development and behavior in mice
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6
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