Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice

Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.

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Autores principales:	Virginie Courchet, Amanda J. Roberts, Géraldine Meyer-Dilhet, Peggy Del Carmine, Tommy L. Lewis, Franck Polleux, Julien Courchet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6
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spelling	oai:doaj.org-article:86a0b1965c3547f0820ef0dd3daf13b62021-12-02T14:39:47ZHaploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice10.1038/s41467-018-06584-52041-1723https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06584-5https://doaj.org/toc/2041-1723Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.Virginie CourchetAmanda J. RobertsGéraldine Meyer-DilhetPeggy Del CarmineTommy L. LewisFranck PolleuxJulien CourchetNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Virginie Courchet Amanda J. Roberts Géraldine Meyer-Dilhet Peggy Del Carmine Tommy L. Lewis Franck Polleux Julien Courchet Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
description	Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.
format	article
author	Virginie Courchet Amanda J. Roberts Géraldine Meyer-Dilhet Peggy Del Carmine Tommy L. Lewis Franck Polleux Julien Courchet
author_facet	Virginie Courchet Amanda J. Roberts Géraldine Meyer-Dilhet Peggy Del Carmine Tommy L. Lewis Franck Polleux Julien Courchet
author_sort	Virginie Courchet
title	Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_short	Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_full	Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_fullStr	Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_full_unstemmed	Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
title_sort	haploinsufficiency of autism spectrum disorder candidate gene nuak1 impairs cortical development and behavior in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6
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Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice

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