Haploinsufficiency of autism spectrum disorder candidate gene NUAK1 impairs cortical development and behavior in mice
Nuak1 is an autism spectrum disorder candidate gene. Here the authors report behavioral and cortical development in mice heterozygous for Nuak1, suggesting loss of function mutations in one copy of Nuak1 may contribute to neurodevelopmental disorders.
Guardado en:
Autores principales: | Virginie Courchet, Amanda J. Roberts, Géraldine Meyer-Dilhet, Peggy Del Carmine, Tommy L. Lewis, Franck Polleux, Julien Courchet |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/86a0b1965c3547f0820ef0dd3daf13b6 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
NUAK2 is a critical YAP target in liver cancer
por: Wei-Chien Yuan, et al.
Publicado: (2018) -
NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism
por: Shichun Tu, et al.
Publicado: (2017) -
Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder
por: Job O. de Jong, et al.
Publicado: (2021) -
Astroglia in Autism Spectrum Disorder
por: Kinga Gzielo, et al.
Publicado: (2021) -
The pathogenesis of autism spectrum disorder
por: Beatriz Sanabria-Barradas, et al.
Publicado: (2021)