Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferation.
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Nature Portfolio
2017
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oai:doaj.org-article:86a25a0c882247c39b38bbcac00ca5392021-12-02T14:40:57ZInterleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme10.1038/s41467-017-01392-92041-1723https://doaj.org/article/86a25a0c882247c39b38bbcac00ca5392017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01392-9https://doaj.org/toc/2041-1723Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferation.Jennifer P. NewmanGrace Y. WangKazuhiko ArimaShou P. GuanMichael R. WatersWebster K. CaveneeEdward PanEdita AliwargaSiao T. ChongCatherine Y. L. KokBerwini B. EndayaAmyn A. HabibTomohisa HoribeWai H. NgIvy A. W. HoKam M. HuiTomasz KordulaPaula Y. P. LamNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jennifer P. Newman Grace Y. Wang Kazuhiko Arima Shou P. Guan Michael R. Waters Webster K. Cavenee Edward Pan Edita Aliwarga Siao T. Chong Catherine Y. L. Kok Berwini B. Endaya Amyn A. Habib Tomohisa Horibe Wai H. Ng Ivy A. W. Ho Kam M. Hui Tomasz Kordula Paula Y. P. Lam Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme |
| description |
Interleukin-13 receptor alpha 2 is highly expressed in glioblastoma multiforme but its role in this malignancy is unclear. Here the authors show that this receptor interacts with mutant EGFR, stimulating its kinase activity, thus inducing proliferation. |
| format |
article |
| author |
Jennifer P. Newman Grace Y. Wang Kazuhiko Arima Shou P. Guan Michael R. Waters Webster K. Cavenee Edward Pan Edita Aliwarga Siao T. Chong Catherine Y. L. Kok Berwini B. Endaya Amyn A. Habib Tomohisa Horibe Wai H. Ng Ivy A. W. Ho Kam M. Hui Tomasz Kordula Paula Y. P. Lam |
| author_facet |
Jennifer P. Newman Grace Y. Wang Kazuhiko Arima Shou P. Guan Michael R. Waters Webster K. Cavenee Edward Pan Edita Aliwarga Siao T. Chong Catherine Y. L. Kok Berwini B. Endaya Amyn A. Habib Tomohisa Horibe Wai H. Ng Ivy A. W. Ho Kam M. Hui Tomasz Kordula Paula Y. P. Lam |
| author_sort |
Jennifer P. Newman |
| title |
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme |
| title_short |
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme |
| title_full |
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme |
| title_fullStr |
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme |
| title_full_unstemmed |
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme |
| title_sort |
interleukin-13 receptor alpha 2 cooperates with egfrviii signaling to promote glioblastoma multiforme |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/86a25a0c882247c39b38bbcac00ca539 |
| work_keys_str_mv |
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